《化脓性汗腺炎患者的身体成分和基础代谢率：基于丹麦人群和医院的横断面研究》。

Body composition and basal metabolic rate in Hidradenitis Suppurativa: a Danish population-based and hospital-based cross-sectional study.

机构信息

Department of Dermatology, Roskilde Hospital, Roskilde, Denmark.

Department of Biostatistics, University of Copenhagen, Copenhagen, Denmark.

出版信息

J Eur Acad Dermatol Venereol. 2016 Jun;30(6):980-8. doi: 10.1111/jdv.13522. Epub 2015 Dec 9.

DOI:10.1111/jdv.13522

PMID:26660945

Abstract

BACKGROUND

Several studies have suggested an association between Hidradenitis Suppurativa (HS) and obesity. Obesity is often expressed as Body Mass Index (BMI). However, BMI lacks information on body composition. General obesity is a predictor of health status and cardiovascular risk, but body composition (e.g. abdominal fat) may be more so. Basal metabolic rate (BMR) is an expression of resting metabolism and may serve as a complementary tool when assessing the possibly underlying metabolism behind a persons' body composition.

OBJECTIVE

To investigate the body composition and basal metabolic rate in individuals with HS compared with healthy controls.

METHODS

We performed a cross-sectional study on both a hospital-based and population-based HS group and compared with controls using Bioelectrical Impedance Analysis to assess body composition.

RESULTS

We identified a hospital-based HS group of 32 hospital HS patients, a population-based HS group of 430 population HS patients, and 20 780 controls. Age- and sex-adjusted analyses showed a 10.12% (P < 0.0001) significantly higher fat percentage in the hospital-based HS group and 3.11% (P < 0.0001) significantly higher fat percentage for the population-based HS group compared to controls. Correspondingly, the HS groups had a lower muscle percentage (P < 0.0001) and lower bone mass percentage (P < 0.0001). Furthermore, visceral fat rating (P < 0.0001), Body Mass Index (P < 0.0001), waist circumference (P < 0.0001), and Waist/Hip Ratio (P < 0.0001) was significantly higher in HS patients compared with controls. Additionally, age and sex-adjusted analyses showed a higher predicted estimate of BMR for the HS groups compared with controls (154.56 kcal/day (95% CI 54.96-254.16) (P = 0.0031) for the hospital-based HS group, and 82.63 kcal/day (95%CI 59.70-105.56) (P < 0.0001) for the population-based HS group).

CONCLUSION

Hidradenitis Suppurativa is associated with a high fat percentage, high visceral fat, and low muscle percentage adding to the morbidity of HS. The higher predicted estimate of basal metabolic rate (BMR) in HS patients may reflect a dysfunctional metabolism contributing to the high-fat-body composition.

摘要

背景

多项研究表明，化脓性汗腺炎（HS）与肥胖之间存在关联。肥胖通常用体重指数（BMI）表示。然而，BMI 缺乏关于身体成分的信息。一般肥胖是健康状况和心血管风险的预测因素，但身体成分（如腹部脂肪）可能更重要。基础代谢率（BMR）是静息代谢的一种表现形式，在评估个体身体成分背后可能存在的代谢情况时，可能是一种补充工具。

目的

调查化脓性汗腺炎患者与健康对照组之间的身体成分和基础代谢率。

方法

我们对医院为基础的化脓性汗腺炎组和人群为基础的化脓性汗腺炎组进行了横断面研究，并使用生物电阻抗分析来评估身体成分，与对照组进行了比较。

结果

我们确定了一个由 32 名医院化脓性汗腺炎患者组成的医院化脓性汗腺炎组、一个由 430 名人群化脓性汗腺炎患者组成的人群化脓性汗腺炎组和 20780 名对照组。年龄和性别调整分析显示，医院化脓性汗腺炎组的脂肪百分比高出 10.12%（P < 0.0001），人群化脓性汗腺炎组的脂肪百分比高出 3.11%（P < 0.0001），明显高于对照组。相应地，HS 组的肌肉百分比较低（P < 0.0001），骨量百分比较低（P < 0.0001）。此外，HS 患者的内脏脂肪评分（P < 0.0001）、体重指数（P < 0.0001）、腰围（P < 0.0001）和腰臀比（P < 0.0001）明显高于对照组。此外，年龄和性别调整分析显示，HS 组的基础代谢率（BMR）预测值高于对照组（医院化脓性汗腺炎组为 154.56 千卡/天（95%CI 54.96-254.16）（P = 0.0031），人群化脓性汗腺炎组为 82.63 千卡/天（95%CI 59.70-105.56）（P < 0.0001））。