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色素上皮衍生因子，一种体内光感受器的保护因子。

Pigment Epithelium-Derived Factor, a Protective Factor for Photoreceptors in Vivo.

作者信息

Polato Federica, Becerra S Patricia

机构信息

Section of Protein Structure and Function, Laboratory of Retinal Cell and Molecular Biology, NEI, National Institutes of Health, NIH-NEI BG.6. Room 134. 6 Center Drive MSC 0608, 20892-0608, Bethesda, MD, USA.

出版信息

Adv Exp Med Biol. 2016;854:699-706. doi: 10.1007/978-3-319-17121-0_93.

DOI:10.1007/978-3-319-17121-0_93
PMID:26427478
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7787428/
Abstract

Pigment epithelium-derived factor (PEDF) is a natural protein of the retina with demonstrable neurotrophic properties, found in the interphotoreceptor matrix in intimate contact with photoreceptors. This review summarizes the effects of PEDF on photoreceptors in several animal models of retinal degeneration.

摘要

色素上皮衍生因子（PEDF）是视网膜中的一种天然蛋白质，具有明显的神经营养特性，存在于与光感受器紧密接触的光感受器间基质中。本综述总结了PEDF在几种视网膜变性动物模型中对光感受器的作用。

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本文引用的文献

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Pigment epithelium-derived factor reduces apoptosis and pro-inflammatory cytokine gene expression in a murine model of focal retinal degeneration.色素上皮衍生因子可减少鼠类局灶性视网膜变性模型中的细胞凋亡和促炎细胞因子基因表达。
ASN Neuro. 2013 Nov 26;5(5):e00126. doi: 10.1042/AN20130028.
2
Pigment epithelium-derived factor (PEDF) prevents retinal cell death via PEDF Receptor (PEDF-R): identification of a functional ligand binding site.色素上皮衍生因子 (PEDF) 通过 PEDF 受体 (PEDF-R) 防止视网膜细胞死亡：鉴定功能性配体结合位点。
J Biol Chem. 2013 Aug 16;288(33):23928-42. doi: 10.1074/jbc.M113.487884. Epub 2013 Jul 1.
3
The effects of PEDF on cancer biology: mechanisms of action and therapeutic potential.PEDF 对癌症生物学的影响：作用机制与治疗潜力。
Nat Rev Cancer. 2013 Apr;13(4):258-71. doi: 10.1038/nrc3484. Epub 2013 Mar 14.
4
Photoreceptor rescue of pigment epithelium-derived factor-impregnated nanoparticles in Royal College of Surgeons rats.皇家外科学院大鼠中色素上皮衍生因子浸渍纳米颗粒的光感受器挽救作用
Mol Vis. 2012;18:3079-86. Epub 2012 Dec 29.
5
Controversial view of a genetically altered mouse model of focal retinal degeneration.关于局灶性视网膜变性的基因改造小鼠模型的争议观点。
Bioengineered. 2013 May-Jun;4(3):130-5. doi: 10.4161/bioe.22949. Epub 2012 Nov 29.
6
Photoreceptor cell death mechanisms in inherited retinal degeneration.遗传性视网膜变性中的光感受器细胞死亡机制。
Mol Neurobiol. 2008 Dec;38(3):253-69. doi: 10.1007/s12035-008-8045-9. Epub 2008 Nov 4.
7
Inhibition of nuclear translocation of apoptosis-inducing factor is an essential mechanism of the neuroprotective activity of pigment epithelium-derived factor in a rat model of retinal degeneration.抑制凋亡诱导因子的核转位是色素上皮衍生因子在大鼠视网膜变性模型中发挥神经保护活性的重要机制。
Am J Pathol. 2008 Nov;173(5):1326-38. doi: 10.2353/ajpath.2008.080466. Epub 2008 Oct 9.
8
Identification of a lipase-linked cell membrane receptor for pigment epithelium-derived factor.鉴定色素上皮衍生因子的一种脂酶连接细胞膜受体。
J Biol Chem. 2006 Dec 8;281(49):38022-37. doi: 10.1074/jbc.M600353200. Epub 2006 Oct 10.
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Focus on Molecules: Pigment epithelium-derived factor (PEDF).聚焦分子：色素上皮衍生因子（PEDF）。
Exp Eye Res. 2006 May;82(5):739-40. doi: 10.1016/j.exer.2005.10.016. Epub 2005 Dec 20.
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Intraocular gene transfer of pigment epithelium-derived factor rescues photoreceptors from light-induced cell death.色素上皮衍生因子的眼内基因转移可挽救光诱导细胞死亡中的光感受器。
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