National Eye Institute, US National Institutes of Health, Bethesda, Maryland, USA.
Nat Rev Cancer. 2013 Apr;13(4):258-71. doi: 10.1038/nrc3484. Epub 2013 Mar 14.
The potent actions of pigment epithelium-derived factor (PEDF) on tumour-associated cells, and its extracellular localization and secretion, stimulated research on this multifunctional serpin. Such studies have identified several PEDF receptors and downstream signalling pathways. Known cellular PEDF responses have expanded from the initial discovery that PEDF induces retinoblastoma cell differentiation to its anti-angiogenic, antitumorigenic and antimetastatic properties. Although the diversity of PEDF activities seems to be complex, they are consistent with the varied mechanisms that regulate this multimodal factor. If PEDF is to be used for cancer management, a deeper appreciation of its many functions and mechanisms of action is needed.
色素上皮衍生因子 (PEDF) 对肿瘤相关细胞的强大作用及其细胞外定位和分泌，激发了对这种多功能丝氨酸蛋白酶抑制剂的研究。此类研究已鉴定出几种 PEDF 受体和下游信号通路。已知的细胞 PEDF 反应已从最初的发现扩展，即 PEDF 诱导视网膜母细胞瘤细胞分化，到其抗血管生成、抗肿瘤和抗转移特性。尽管 PEDF 的活性多样性似乎很复杂，但它们与调节这种多模式因子的各种机制一致。如果要将 PEDF 用于癌症管理，则需要更深入地了解其许多功能和作用机制。
