Bagheri Seyyed Majid, Hedesh Sadegh Taghizade, Mirjalili Aghdas, Dashti-R Mohammad Hossein
Department of Physiology, Shahid Sadoghi University of Medical Sciences, Yazd, Iran
School of Medicine, Shahid Sadoghi University of Medical Sciences, Yazd, Iran.
J Evid Based Complementary Altern Med. 2016 Oct;21(4):271-6. doi: 10.1177/2156587215605903. Epub 2015 Sep 30.
Asafetida is well known for its medicinal and therapeutic values in Iranian folk medicine. This study was conducted to investigate the antinociceptive and anti-inflammatory effects of asafetida. In hot plate test, asafetida exhibited a significant antinociceptive effect at all administered doses and the most effective dose was 10 mg/kg. The highest maximum potent effect was observed 15 minutes after asafetida administration. The antinociceptive effect of asafetida was not reversed by administration of any antagonist used in this study but asafetida showed a remarkable antioxidant and also inhibitory action against lipoxygenase activity. Paw weight was significantly reduced only in treated animals with 2.5 mg/kg asafetida. Results clearly indicate that the asafetida could be a potential source of anti-inflammatory and analgesic agent. These effects may be due to its effective constituents such as monoterpenes, flavonoids and phenolic components that have antioxidant properties and inhibit lipoxygenase activity.
在伊朗民间医学中，阿魏因其药用和治疗价值而闻名。本研究旨在探讨阿魏的抗伤害感受和抗炎作用。在热板试验中，阿魏在所有给药剂量下均表现出显著的抗伤害感受作用，最有效的剂量为10毫克/千克。在给予阿魏后15分钟观察到最高的最大有效作用。本研究中使用的任何拮抗剂给药均未逆转阿魏的抗伤害感受作用，但阿魏显示出显著的抗氧化作用以及对脂氧合酶活性的抑制作用。仅在给予2.5毫克/千克阿魏的治疗动物中爪重量显著降低。结果清楚地表明，阿魏可能是抗炎和镇痛剂的潜在来源。这些作用可能归因于其有效的成分，如具有抗氧化特性并抑制脂氧合酶活性的单萜、黄酮类化合物和酚类成分。
