Zare-Bidoki Reza, Afrasiabi Ali, Hajatmand-Targhi Fatemeh Zahra, Rahimi Hossein, Bagheri Seyyed Majid
Faculty of Medicine, Student Research Committee, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Department of Physiology, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Curr Pharm Des. 2025;31(30):2402-2415. doi: 10.2174/0113816128342341250130050721.
Cancer is a challenging and lethal illness, with the number of individuals affected on the rise, particularly in developing nations. This disease incurs significant expenses for both patients and governments annually. Conversely, even with various methods and treatments in use, the mortality rate remains elevated. Additionally, traditional therapies come with numerous side effects, and drug resistance presents another obstacle for physicians. Consequently, discovering new drugs derived from natural sources may be a method to combat cancer. Ferula plants contain different metabolites, including monoterpenes, sulfide compounds, and polyphenols that are beneficial in cancer therapy.
This article was assembled to gather evidence and literature concerning the anticancer properties of compounds derived from these plants.
This review article was created by exploring the term isolated constituents and cancer, with related data gathered from electronic databases such as ISI Web of Knowledge, PubMed, and Google Scholar up until early 2024.
Results revealed that quite extensive research has been done in this area, indicating that the compounds may serve as novel medications for cancer therapy.
Subsequent research should encompass animal studies or clinical trials, focusing on assessing toxicity and identifying effective doses against cancer to facilitate the application of these natural derivatives in cancer treatment.
癌症是一种具有挑战性的致命疾病，受影响的人数正在上升，尤其是在发展中国家。这种疾病每年给患者和政府都带来巨大的费用。相反，即使使用了各种方法和治疗手段，死亡率仍然居高不下。此外，传统疗法有许多副作用，耐药性也给医生带来了另一个障碍。因此，发现源自天然来源的新药可能是对抗癌症的一种方法。阿魏属植物含有不同的代谢产物，包括单萜类、硫化物化合物和多酚，这些物质在癌症治疗中有益。
本文旨在收集有关这些植物衍生化合物抗癌特性的证据和文献。
这篇综述文章通过搜索“分离成分与癌症”这一术语创建，相关数据截至2024年初从诸如科学网、PubMed和谷歌学术等电子数据库收集。
结果表明，该领域已经进行了相当广泛的研究，表明这些化合物可能作为癌症治疗的新型药物。
后续研究应包括动物研究或临床试验，重点评估毒性并确定抗癌有效剂量，以促进这些天然衍生物在癌症治疗中的应用。
