CAU&ACC Joint-Laboratory of Space Food, Beijing Laboratory for Food Quality and Safety, College of Food Science & Nutritional Engineering, Beijing Dairy industry Innovation Team, China Agricultural University, No.17 Qinghua East Road, Haidian, Beijing 100083, PR China.
CAU&ACC Joint-Laboratory of Space Food, Beijing Laboratory for Food Quality and Safety, College of Food Science & Nutritional Engineering, Beijing Dairy industry Innovation Team, China Agricultural University, No.17 Qinghua East Road, Haidian, Beijing 100083, PR China.
Carbohydr Polym. 2015 Dec 10;134:158-66. doi: 10.1016/j.carbpol.2015.07.065. Epub 2015 Jul 29.
Chitosan-stabilized selenium nanoparticles (SeNPs) have been reported, but there is no information on the effect of the chitosan molecular weight on the structure, stability, and selenium release properties of the SeNPs. Herein, we compared the uniform Se(0) spherical nanoparticles prepared through the reduction of seleninic acid with ascorbic acid in the presence of chitosan with different molecular weights (Mws). We found that both low and high molecular weight chitosan-stabilized selenium nanoparticles exhibited core-shell microstructures with a size of about 103 nm after 30 days growing through the "bottom-up approach" and "top-down approach," respectively. Moreover, both chitosan SeNPs processed excellent stability towards pH and enzyme treatment. In contrast, selenium was easily released to different extents from these two chitosan SeNPs upon treatment with different free radicals. This makes these materials potentially useful as oral antioxidant supplements.
壳聚糖稳定的硒纳米颗粒（SeNPs）已有报道，但关于壳聚糖分子量对 SeNPs 的结构、稳定性和硒释放性能的影响尚无信息。在此，我们比较了通过在不同分子量（Mw）的壳聚糖存在下用抗坏血酸还原亚硒酸制备的均匀 Se(0)球形纳米颗粒。我们发现，在通过“自下而上”和“自上而下”方法分别生长 30 天后，低分子量和高分子量壳聚糖稳定的硒纳米颗粒均表现出核壳微结构，尺寸约为 103nm。此外，两种壳聚糖 SeNPs 在 pH 和酶处理方面均表现出出色的稳定性。相比之下，这两种壳聚糖 SeNPs 在受到不同自由基处理时，硒的释放程度不同。这使得这些材料有可能用作口服抗氧化补充剂。
