壳聚糖和羧甲基纤维素钠包覆硒纳米粒子的稳定性和表面性能。
Stability and surface properties of selenium nanoparticles coated with chitosan and sodium carboxymethyl cellulose.
机构信息
Key Laboratory of Functional Dairy, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China; Key Laboratory of Precision Nutrition and Food Quality, Ministry of Education, China Agricultural University, Beijing 100083, China.
Department F. A. Forel for Environmental and Aquatic Sciences, Section of Earth and Environmental Sciences and Institute for Environmental Sciences, University of Geneva, Carl-Vogt 66, CH-1211 Geneva, Switzerland.
出版信息
Carbohydr Polym. 2022 Feb 15;278:118859. doi: 10.1016/j.carbpol.2021.118859. Epub 2021 Nov 4.
The effect of polysaccharide coatings on the stability and release characteristics of selenium nanoparticles (SeNPs) was evaluated by comparing the characteristics of chitosan-coated SeNPs (CS-SeNPs) and sodium carboxymethyl cellulose-coated SeNPs (CMC-SeNPs). The release characteristics of SeNPs were investigated in storage conditions, gastrointestinal conditions, and free radical systems. CMC-SeNPs formed dimers or trimers, whereas CS-SeNPs were monodispersed but formed large aggregates in a pH range of 7.4-8.25. Upon 50 days of storage at 30 °C, both CMC-SeNPs and CS-SeNPs were converted to Se. SeNPs exhibited a lower release rate in simulated gastrointestinal conditions than in free radical systems. SeNPs release in ABTS and superoxide anion free radical systems followed the first-order and Korsmeyer-Peppas models, respectively, indicating that SeNP release is mainly governed by dissolution mechanisms. Additional studies are needed to examine the potential environmental effects and biological activity of the Se released from SeNPs.
通过比较壳聚糖包裹的硒纳米颗粒（CS-SeNPs）和羧甲基纤维素钠包裹的硒纳米颗粒（CMC-SeNPs）的特性，评估多糖涂层对硒纳米颗粒（SeNPs）稳定性和释放特性的影响。在储存条件、胃肠道条件和自由基体系中研究了 SeNPs 的释放特性。CMC-SeNPs 形成二聚体或三聚体，而 CS-SeNPs 在 pH 值为 7.4-8.25 范围内则呈单分散状态，但形成大聚集体。在 30°C 下储存 50 天后，CMC-SeNPs 和 CS-SeNPs 都转化为 Se。与自由基体系相比，SeNPs 在模拟胃肠道条件下的释放率较低。ABTS 和超氧阴离子自由基体系中 SeNPs 的释放分别遵循一级和 Korsmeyer-Peppas 模型，表明 SeNP 释放主要受溶解机制控制。需要进一步研究从 SeNPs 释放的 Se 的潜在环境影响和生物活性。
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