Bardellini E, Tonni I, Micheli R, Molinaro A, Amadori F, Flocchini P, Piana G, Majorana A
Department of Paediatric Dentistry, Dental School, University of Brescia, Brescia, Italy.
Unit of Child Neurology and Psychiatry, Spedali Civili, Brescia, Italy.
Orthod Craniofac Res. 2016 Feb;19(1):46-53. doi: 10.1111/ocr.12108. Epub 2015 Oct 2.
Literature is poor of data about the occlusion in children affected by neurofibromatosis type 1 (NF1). This case-control study investigated the occlusal traits in a group of children with NF1.
A hundred and fifteen children with NF1 were enrolled; non-NF1 controls were sequentially selected among subjects referred to the Pediatric Dentistry Department.
All patients underwent a clinical dental examination and a panoramic radiography. The following orthodontic variables were considered: molar relationship, overjet, overbite, cross-bite, scissor bite, and crowding/spacing.
Class III molar relationship resulted significantly (p = 0.01) more common in children with NF1 than in the control group as well as the unilateral posterior cross-bite (p = 0.0017). Forty-three children with NF1 (37.3%) showed radiographic abnormalities; in one case, a plexiform neurofibroma was detected.
An early orthodontic evaluation might be planned in the management of children with NF1 to prevent or decrease the need for extensive orthodontic interventions.
关于1型神经纤维瘤病（NF1）患儿咬合情况的数据在文献中较为匮乏。本病例对照研究调查了一组NF1患儿的咬合特征。
纳入115例NF1患儿；非NF1对照组在转诊至儿童牙科的患者中依次选取。
所有患者均接受临床口腔检查和全景X线摄影。考虑以下正畸变量：磨牙关系、覆盖、覆合、反合、剪刀合以及拥挤/间隙。
Ⅲ类磨牙关系在NF1患儿中比对照组显著更常见（p = 0.01），单侧后牙反合也是如此（p = 0.0017）。43例NF1患儿（37.3%）显示有影像学异常；其中1例检测到丛状神经纤维瘤。
在NF1患儿的管理中，可能需要进行早期正畸评估，以预防或减少广泛正畸干预的需求。
