用于生成中等至大型含立体中心的双环[n.3.1]磷酸酯的磷酸酯连接介导的闭环复分解反应。
Phosphate Tether-Mediated Ring-Closing Metathesis for the Generation of Medium to Large, -Stereogenic Bicyclo[n.3.1]phosphates.
作者信息
Maitra Soma, Markley Jana L, Chegondi Rambabu, Hanson Paul R
机构信息
Department of Chemistry, University of Kansas, 1251 Wescoe Hall Drive, Lawrence, KS 66045-7582.
出版信息
Tetrahedron. 2015 Sep 2;71(35):5734-5740. doi: 10.1016/j.tet.2015.06.016.
Abstract
A phosphate tether-mediated ring-closing metathesis study towards the synthesis of -stereogenic bicyclo[6.3.1]-, bicyclo[7.3.1]-, and bicyclo[8.3.1]phosphates is reported. This study demonstrates expanded utility of phosphate tether-mediated desymmetrization of -symmetric, 1,3--diol dienes in generating complex medium to large, -stereogenic bicyclo[n.3.1]phosphates..
摘要
报道了一项关于通过磷酸酯连接介导的闭环复分解反应合成具有β-立体中心的双环[6.3.1]、双环[7.3.1]和双环[8.3.1]磷酸酯的研究。该研究表明，磷酸酯连接介导的对称、1,3-二羟基二烯的去对称化在生成复杂的中到大尺寸、具有β-立体中心的双环[n.3.1]磷酸酯方面具有更广泛的应用。
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