某些天然化合物在沙门氏菌/微粒体试验中对香烟烟雾冷凝物和苯并[a]芘的抗诱变活性。

Antimutagenic activity of some naturally occurring compounds towards cigarette-smoke condensate and benzo[a]pyrene in the Salmonella/microsome assay.

作者信息

Terwel L, van der Hoeven J C

出版信息

Mutat Res. 1985 Oct;152(1):1-4. doi: 10.1016/0027-5107(85)90039-9.

Abstract

Several compounds, occurring in food, were tested for antimutagenic activity towards cigarette-smoke condensate (CSC) and benzo[a]pyrene (BaP). Antimutagenicity was determined in the Salmonella/microsome test, with tester strain TA98, in the presence of rat-liver homogenate. Dose-response curves did show reduction of CSC- and BaP-induced mutagenicity by ellagic acid, riboflavin and chlorophyllin. Chlorophyll a and chlorophyll b, although less distinct, also inhibited CSC- and BaP-induced mutagenicity. Ascorbic acid, beta-carotene, tocopherol acetate, chlorogenic acid and butyl hydroxyanisole did not have any influence on the mutagenicity of CSC and BaP. The similarity in results for cigarette-smoke condensate and for BaP indicates that a general mechanism may be involved in the inhibition of CSC- and BaP-induced mutagenicity.

摘要

对食品中存在的几种化合物进行了测试，以检测其对香烟烟雾冷凝物（CSC）和苯并[a]芘（BaP）的抗诱变活性。在沙门氏菌/微粒体试验中，使用测试菌株TA98，在大鼠肝脏匀浆存在的情况下测定抗诱变性。剂量反应曲线确实显示，鞣花酸、核黄素和叶绿酸可降低CSC和BaP诱导的诱变性。叶绿素a和叶绿素b虽然不太明显，但也能抑制CSC和BaP诱导的诱变性。抗坏血酸、β-胡萝卜素、醋酸生育酚、绿原酸和丁基羟基茴香醚对CSC和BaP的诱变性没有任何影响。香烟烟雾冷凝物和BaP的结果相似，表明可能存在一种普遍机制参与抑制CSC和BaP诱导的诱变性。