Durrett Richard, Moseley Stephen
Department of Mathematics, Box 90320, Duke U., Durham NC 27708-0320.
Ann Appl Probab. 2015 Feb;25(1):104-115. doi: 10.1214/13-AAP989.
We consider a multistage cancer model in which cells are arranged in a -dimensional integer lattice. Starting with all wild-type cells, we prove results about the distribution of the first time when two neutral mutations have accumulated in some cell in dimensions ≥ 2, extending work done by Komarova [12] for = 1.
我们考虑一个多阶段癌症模型，其中细胞排列在一个(d)维整数格点上。从所有野生型细胞开始，我们证明了关于在(d\geq2)维中某个细胞积累两个中性突变的首次时间分布的结果，扩展了Komarova [12]在(d = 1)时所做的工作。
