Younis Bilal Bin, Arshad Rozina, Khurhsid Saima, Masood Junaid, Nazir Farhan, Tahira Maham
Bilal Bin Younis, Sakina Institute of Diabetes and Endocrine Research, Shamalar Medical & Dental College Hospital, Lahore, Pakistan.
Rozina Arshad, Sakina Institute of Diabetes and Endocrine Research, Shamalar Medical & Dental College Hospital, Lahore, Pakistan.
Pak J Med Sci. 2015 Jul-Aug;31(4):1009-11. doi: 10.12669/pjms.314.7618.
Acute hepatitis C (HCV) infection has been identified as an important cause of fulminant hepatic failure (FHF), characterized by rapid deterioration of liver function from massive hepatic necrosis leading to encephalopathy and multi-organ failure. We admitted a female patient at Shalamar Hospital with jaundice, fever, encephalopathy and coagulopathy of short duration with no history of any comorbidity. Her hepatitis viral screen revealed positive anti HCV. Her viral loads were also high. A diagnosis of FHF due to acute HCV infection was made. Patient was treated conservatively and improved gradually. In summary, acute HCV can cause FHF and should be ruled out in patients with FHF of unknown cause in an endemic country for HCV like Pakistan.
急性丙型肝炎病毒（HCV）感染已被确认为暴发性肝衰竭（FHF）的重要病因，其特征是由于大量肝坏死导致肝功能迅速恶化，进而引发脑病和多器官功能衰竭。我们在沙勒马尔医院收治了一名女性患者，她出现黄疸、发热、脑病和凝血功能障碍，病程较短，无任何合并症病史。她的肝炎病毒筛查显示抗HCV呈阳性。她的病毒载量也很高。诊断为急性HCV感染所致的FHF。患者接受了保守治疗并逐渐好转。总之，急性HCV可导致FHF，在像巴基斯坦这样HCV流行的国家，对于病因不明的FHF患者应排除急性HCV感染。
