1.2%磷酸克林霉素/3.75%过氧化苯甲酰凝胶与粉底液的随机、观察者盲法、半脸相容性研究
Randomized, Observer-blind, Split-face Compatibility Study with Clindamycin Phosphate 1.2%/Benzoyl Peroxide 3.75% gel and Facial Foundation Makeup.
作者信息
Bhatia Neal, Pillai Radhakrishnan
机构信息
Therapeutics Clinical Research, San Diego, California;
Dow Pharmaceutical Sciences Inc. (a division of Valeant Pharmaceuticals), Petaluma, California.
出版信息
J Clin Aesthet Dermatol. 2015 Sep;8(9):25-32.
BACKGROUND
Cosmetic compatibility in the treatment of acne is an important issue significantly impacting quality of life, but often overlooked, as dermatologists commonly recommended avoidance of cosmetic foundations when treating adult female patients. Fixed combinations of clindamycin/benzoyl peroxide are widely used in the treatment of acne, but little is known about the impact of their concomitant use with facial foundation.
OBJECTIVE
To assess the compatibility of clindamycin phosphate 1. 2%/benzoyl peroxide 3. 75% gel with foundation makeup for up to six hours after application.
METHODS
Twenty-nine female subjects applied makeup to their face after randomly applying clindamycin phosphate 1. 2%/benzoyl peroxide 3. 75% gel to one side of the face. Investigator and subject self- assessment included facial skin attributes, facial tolerability, and cosmetic compatibility post-application and at Hour 6; as well as cutaneous tolerability.
RESULTS
No statistical difference was noted between the treated and untreated side of the face in terms of coverage, blotchiness, appearance, skin tone, or visual smoothness. Tolerability was excellent, with no erythema, edema, dryness, and peeling post-makeup application. For both the treated and untreated side, there was a slight lack of improvement in cosmetic appearance six hours post-makeup application.
CONCLUSION
Clindamycin/benzoyl peroxide 3. 75% gel was shown to have excellent cosmetic compatibility with facial foundation.
背景
痤疮治疗中的化妆品兼容性是一个对生活质量有重大影响的重要问题，但常常被忽视，因为皮肤科医生在治疗成年女性患者时通常建议避免使用粉底。克林霉素/过氧化苯甲酰的固定组合被广泛用于痤疮治疗，但关于它们与粉底同时使用的影响知之甚少。
目的
评估1.2%克林霉素磷酸酯/3.75%过氧化苯甲酰凝胶在涂抹后长达6小时与粉底的兼容性。
方法
29名女性受试者在一侧面部随机涂抹1.2%克林霉素磷酸酯/3.75%过氧化苯甲酰凝胶后在面部化妆。研究者和受试者的自我评估包括涂抹后及6小时后的面部皮肤属性、面部耐受性、化妆品兼容性以及皮肤耐受性。
结果
在遮盖力、斑点、外观、肤色或视觉光滑度方面，面部治疗侧和未治疗侧之间未观察到统计学差异。耐受性良好，化妆后无红斑、水肿、干燥和脱皮现象。对于治疗侧和未治疗侧，化妆6小时后化妆品外观略有改善不足。
结论
克林霉素/3.75%过氧化苯甲酰凝胶与粉底具有出色的化妆品兼容性。
Zotero 插件