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Emerging Issues in Adult Female Acne.成年女性痤疮的新问题
J Clin Aesthet Dermatol. 2017 Jan;10(1):37-46. Epub 2017 Jan 1.
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Sub-group Analyses from a Trial of a Fixed Combination of Clindamycin Phosphate 1.2% and Benzoyl Peroxide 3.75% Gel for the Treatment of Moderate-to-severe Acne Vulgaris.一项关于1.2%克林霉素磷酸酯与3.75%过氧化苯甲酰凝胶固定组合治疗中度至重度寻常痤疮试验的亚组分析。
J Clin Aesthet Dermatol. 2015 Dec;8(12):22-6.

本文引用的文献

1
An aqueous gel fixed combination of clindamycin phosphate 1.2% and benzoyl peroxide 3.75% for the once-daily treatment of moderate to severe acne vulgaris.一种含有1.2%磷酸克林霉素和3.75%过氧化苯甲酰的水性凝胶固定组合，用于每日一次治疗中度至重度寻常痤疮。
J Drugs Dermatol. 2014 Sep;13(9):1083-9.
2
Topical antimicrobial acne treatment tolerability: a meaningful factor in treatment adherence?局部抗菌痤疮治疗的耐受性：治疗依从性的一个重要因素？
J Am Acad Dermatol. 2014 Sep;71(3):581-582.e2. doi: 10.1016/j.jaad.2014.01.883.
3
Emotional benefit of cosmetic camouflage in the treatment of facial skin conditions: personal experience and review.化妆品遮瑕在面部皮肤状况治疗中的情绪益处：个人经验和综述。
Clin Cosmet Investig Dermatol. 2012;5:173-82. doi: 10.2147/CCID.S33860. Epub 2012 Nov 1.
4
Fixed-combination products in the management of acne vulgaris.固定复方制剂在寻常痤疮治疗中的应用
Cutis. 2010 Mar;85(3):160-7.
5
New insights into the management of acne: an update from the Global Alliance to Improve Outcomes in Acne group.痤疮管理的新见解：改善痤疮结局全球联盟小组的最新进展
J Am Acad Dermatol. 2009 May;60(5 Suppl):S1-50. doi: 10.1016/j.jaad.2009.01.019.
6
Clinical considerations on the use of concomitant therapy in the treatment of acne.关于在痤疮治疗中使用联合疗法的临床考量
J Dermatolog Treat. 2008;19(4):199-209. doi: 10.1080/09546630802132635.
7
Effects of skin care and makeup under instructions from dermatologists on the quality of life of female patients with acne vulgaris.在皮肤科医生指导下进行皮肤护理和化妆对寻常痤疮女性患者生活质量的影响。
J Dermatol. 2006 Nov;33(11):745-52. doi: 10.1111/j.1346-8138.2006.00174.x.
8
Make-up improves the quality of life of acne patients without aggravating acne eruptions during treatments.化妆可改善痤疮患者的生活质量，且在治疗期间不会加重痤疮发作。
Eur J Dermatol. 2005 Jul-Aug;15(4):284-7.
9
A review of the use of combination therapies for the treatment of acne vulgaris.寻常痤疮联合治疗的应用综述。
J Am Acad Dermatol. 2003 Sep;49(3 Suppl):S200-10. doi: 10.1067/s0190-9622(03)01154-x.
10
Why and when the treatment of acne fails. What to do.痤疮治疗为何失败及何时失败。该怎么办。
Dermatology. 1998;196(1):158-61. doi: 10.1159/000017851.

1.2%磷酸克林霉素/3.75%过氧化苯甲酰凝胶与粉底液的随机、观察者盲法、半脸相容性研究

Randomized, Observer-blind, Split-face Compatibility Study with Clindamycin Phosphate 1.2%/Benzoyl Peroxide 3.75% gel and Facial Foundation Makeup.

作者信息

Bhatia Neal, Pillai Radhakrishnan

机构信息

Therapeutics Clinical Research, San Diego, California;

Dow Pharmaceutical Sciences Inc. (a division of Valeant Pharmaceuticals), Petaluma, California.

出版信息

J Clin Aesthet Dermatol. 2015 Sep;8(9):25-32.

PMID:26430488
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4587892/
Abstract

BACKGROUND

Cosmetic compatibility in the treatment of acne is an important issue significantly impacting quality of life, but often overlooked, as dermatologists commonly recommended avoidance of cosmetic foundations when treating adult female patients. Fixed combinations of clindamycin/benzoyl peroxide are widely used in the treatment of acne, but little is known about the impact of their concomitant use with facial foundation.

OBJECTIVE

To assess the compatibility of clindamycin phosphate 1. 2%/benzoyl peroxide 3. 75% gel with foundation makeup for up to six hours after application.

METHODS

Twenty-nine female subjects applied makeup to their face after randomly applying clindamycin phosphate 1. 2%/benzoyl peroxide 3. 75% gel to one side of the face. Investigator and subject self- assessment included facial skin attributes, facial tolerability, and cosmetic compatibility post-application and at Hour 6; as well as cutaneous tolerability.

RESULTS

No statistical difference was noted between the treated and untreated side of the face in terms of coverage, blotchiness, appearance, skin tone, or visual smoothness. Tolerability was excellent, with no erythema, edema, dryness, and peeling post-makeup application. For both the treated and untreated side, there was a slight lack of improvement in cosmetic appearance six hours post-makeup application.

CONCLUSION

Clindamycin/benzoyl peroxide 3. 75% gel was shown to have excellent cosmetic compatibility with facial foundation.

摘要

背景

痤疮治疗中的化妆品兼容性是一个对生活质量有重大影响的重要问题，但常常被忽视，因为皮肤科医生在治疗成年女性患者时通常建议避免使用粉底。克林霉素/过氧化苯甲酰的固定组合被广泛用于痤疮治疗，但关于它们与粉底同时使用的影响知之甚少。

目的

评估1.2%克林霉素磷酸酯/3.75%过氧化苯甲酰凝胶在涂抹后长达6小时与粉底的兼容性。

方法

29名女性受试者在一侧面部随机涂抹1.2%克林霉素磷酸酯/3.75%过氧化苯甲酰凝胶后在面部化妆。研究者和受试者的自我评估包括涂抹后及6小时后的面部皮肤属性、面部耐受性、化妆品兼容性以及皮肤耐受性。

结果

在遮盖力、斑点、外观、肤色或视觉光滑度方面，面部治疗侧和未治疗侧之间未观察到统计学差异。耐受性良好，化妆后无红斑、水肿、干燥和脱皮现象。对于治疗侧和未治疗侧，化妆6小时后化妆品外观略有改善不足。

结论

克林霉素/3.75%过氧化苯甲酰凝胶与粉底具有出色的化妆品兼容性。