Dall'Oglio Federica, Tedeschi Aurora, Guardabasso Vincenzo, Micali Giuseppe
Dermatology Clinic, University of Catania, Italy.
A.O.U. Policlinico-Vittorio Emanuele of Catania, Italy.
J Clin Aesthet Dermatol. 2015 Sep;8(9):33-8.
To evaluate if nonprescription topical agents may provide positive outcomes in the management of mild-to-moderate facial seborrheic dermatitis by reducing inflammation and scale production through clinical evaluation and erythema-directed digital photography.
Open-label, prospective, not-blinded, intra-patient, controlled, clinical trial (target area).
Twenty adult subjects affected by mild-to-moderate facial seborrheic dermatitis were enrolled and instructed to apply the study cream two times daily, initially on a selected target area only for seven days. If the subject developed visible improvement, it was advised to extend the application to all facial affected area for 21 additional days.
Efficacy was evaluated by measuring the grade of erythema (by clinical examination and by erythema-directed digital photography), desquamation (by clinical examination), and pruritus (by subject-completed visual analog scale). Additionally, at the end of the protocol, a Physician Global Assessment was carried out.
Eighteen subjects completed the study, whereas two subjects were lost to follow-up for nonadherence and personal reasons, respectively. Day 7 data from target areas showed a significant reduction in erythema. At the end of study, a significant improvement was recorded for erythema, desquamation, and pruritus compared to baseline. Physician Global Assessment showed improvement in 89 percent of patients, with a complete response in 56 percent of cases.
These preliminary results indicate that the study cream may be a viable nonprescription therapeutic option for patients affected by facial seborrheic dermatitis able to determine early and significant improvement. This study also emphasizes the advantages of using an erythema-directed digital photography system for assisting in a simple, more accurate erythema severity grading and therapeutic monitoring in patients affected by seborrheic dermatitis.
通过临床评估和红斑定向数码摄影，评估非处方外用制剂是否可通过减轻炎症和鳞屑生成，在轻至中度面部脂溢性皮炎的管理中产生积极效果。
开放标签、前瞻性、非盲、患者内对照临床试验（目标区域）。
招募了20名患有轻至中度面部脂溢性皮炎的成年受试者，并指导他们每天两次涂抹研究乳膏，最初仅在选定的目标区域涂抹7天。如果受试者出现明显改善，建议将涂抹范围扩展至所有面部受累区域，再持续涂抹21天。
通过测量红斑等级（通过临床检查和红斑定向数码摄影）、脱屑（通过临床检查）和瘙痒（通过受试者完成的视觉模拟量表）来评估疗效。此外，在方案结束时，进行了医师整体评估。
18名受试者完成了研究，而另外两名受试者分别因不依从和个人原因失访。目标区域第7天的数据显示红斑明显减轻。在研究结束时，与基线相比，红斑、脱屑和瘙痒均有显著改善。医师整体评估显示89%的患者有改善，56%的病例完全缓解。
这些初步结果表明，对于患有面部脂溢性皮炎的患者，该研究乳膏可能是一种可行的非处方治疗选择，能够实现早期且显著的改善。本研究还强调了使用红斑定向数码摄影系统辅助脂溢性皮炎患者进行简单、更准确的红斑严重程度分级和治疗监测的优势。
