Maduro Morris F
Biology Department; University of California, Riverside ; Riverside, CA USA.
Worm. 2015 Jun 19;4(3):e1046031. doi: 10.1080/21624054.2015.1046031. eCollection 2015 Jul-Sep.
This fall marks 20 years since the cloning of unc-119 was reported. Despite having a strong phenotype that makes animals somewhat difficult to grow and handle, unc-119 mutant rescue has become one of the most frequently-used markers for C. elegans transformation. In this Commentary, I describe the history of how unc-119 rescue traveled through the worm community, contributing to the development of transgene methods in C. elegans.
今年秋天标志着 unc-119 克隆报道 20 周年。尽管 unc-119 突变体具有很强的表型，使得动物的生长和处理有些困难，但 unc-119 突变体拯救已成为秀丽隐杆线虫转化中最常用的标记之一。在这篇评论中，我描述了 unc-119 拯救在线虫研究群体中的发展历程，它对线虫转基因方法的发展起到了推动作用。
