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Capsular Contracture after Breast Augmentation: An Update for Clinical Practice.

作者信息

Headon Hannah, Kasem Adbul, Mokbel Kefah

机构信息

King's College London Medical School, London, UK.

Oncoplastic Breast Surgeon Medway NHS Trust, Kent, UK.

出版信息

Arch Plast Surg. 2015 Sep;42(5):532-43. doi: 10.5999/aps.2015.42.5.532. Epub 2015 Sep 15.


DOI:10.5999/aps.2015.42.5.532
PMID:26430623
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4579163/
Abstract

Capsular contracture is the most common complication following implant based breast surgery and is one of the most common reasons for reoperation. Therefore, it is important to try and understand why this happens, and what can be done to reduce its incidence. A literature search using the MEDLINE database was conducted including search terms 'capsular contracture breast augmentation', 'capsular contracture pathogenesis', 'capsular contracture incidence', and 'capsular contracture management', which yielded 82 results which met inclusion criteria. Capsular contracture is caused by an excessive fibrotic reaction to a foreign body (the implant) and has an overall incidence of 10.6%. Risk factors that were identified included the use of smooth (vs. textured) implants, a subglandular (vs. submuscular) placement, use of a silicone (vs. saline) filled implant and previous radiotherapy to the breast. The standard management of capsular contracture is surgical via a capsulectomy or capsulotomy. Medical treatment using the off-label leukotriene receptor antagonist Zafirlukast has been reported to reduce severity and help prevent capsular contracture from forming, as has the use of acellular dermal matrices, botox and neopocket formation. However, nearly all therapeutic approaches are associated with a significant rate of recurrence. Capsular contracture is a multifactorial fibrotic process the precise cause of which is still unknown. The incidence of contracture developing is lower with the use of textured implants, submuscular placement and the use of polyurethane coated implants. Symptomatic capsular contracture is usually managed surgically, however recent research has focussed on preventing capsular contracture from occurring, or treating it with autologous fat transfer.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1977/4579163/1446023517e9/aps-42-532-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1977/4579163/8f4563ff3530/aps-42-532-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1977/4579163/1446023517e9/aps-42-532-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1977/4579163/8f4563ff3530/aps-42-532-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1977/4579163/1446023517e9/aps-42-532-g002.jpg

相似文献

[1]
Capsular Contracture after Breast Augmentation: An Update for Clinical Practice.

Arch Plast Surg. 2015-9

[2]
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[3]
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[4]
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[5]
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[6]
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[7]
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[8]
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[9]
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[10]
The effect of zafirlukast (Accolate) on early capsular contracture in the primary augmentation patient: a pilot study.

Aesthet Surg J. 2005

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[2]
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[3]
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Plast Reconstr Surg Glob Open. 2025-8-5

[4]
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[5]
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[6]
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[7]
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[8]
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[9]
Protocol for single-arm clinical trial evaluating medical grade polycaprolactone breast scaffold implantation with autologous fat grafting for breast implant revision and congenital defect correction surgery.

BMJ Open. 2025-4-29

[10]
Salvage of the Mastectomy Pocket in Infected Implant-Based Breast Reconstruction Using Negative-Pressure Wound Therapy with Instillation and Dwell: A Systematic Review and Meta-Analysis.

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本文引用的文献

[1]
Update on anaplastic large cell lymphoma in women with breast implants.

Plast Surg (Oakv). 2014

[2]
Effect of Antiadhesion Barrier Solution and Fibrin on Capsular Formation After Silicone Implant Insertion in a White Rat Model.

Aesthetic Plast Surg. 2015-2

[3]
Anaplastic large cell lymphoma (ALCL) and breast implants: breaking down the evidence.

Mutat Res Rev Mutat Res. 2014-8-23

[4]
Breast reconstruction and revision surgery for implant-associated breast deformities using porcine acellular dermal matrix: a multicenter study of 156 cases.

Ann Surg Oncol. 2015-4

[5]
Revisiting Triple Antibiotic Irrigation of Breast Implant Pockets: A Placebo-controlled Single Practice Cohort Study.

Plast Reconstr Surg Glob Open. 2013-11-7

[6]
Autologous Fat Grafting for Treatment of Breast Implant Capsular Contracture: A Study in Pigs.

Aesthet Surg J. 2014-7

[7]
Natrelle round silicone breast implants: Core Study results at 10 years.

Plast Reconstr Surg. 2014-6

[8]
Mast cells in the periprosthetic breast capsule.

Aesthetic Plast Surg. 2014-6

[9]
In vitro and in vivo investigation of the influence of implant surface on the formation of bacterial biofilm in mammary implants.

Plast Reconstr Surg. 2014-4

[10]
The effect of botulinum neurotoxin type A on capsule formation around silicone implants: the in vivo and in vitro study.

Int Wound J. 2016-2

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