Intermountain Medical Center , Transitional Residency Program.
School of Medicine , University of Utah.
Open Forum Infect Dis. 2015 Aug 26;2(4):ofv125. doi: 10.1093/ofid/ofv125. eCollection 2015 Dec.
Q fever is an uncommon but likely underreported zoonotic infection. Severe hyperferritinemia has been associated with hemophagocytic lymphohistiocytosis and other infectious diseases. In this study, we report a case of Coxiella burnetii infection in an asplenic patient complicated by severe hyperferritinemia and bone marrow infiltration. In this case, the marked ferritin elevation may have been an indicator of profound systemic macrophage activation due to preferential intracellular infection of this cell type by C burnetii, perhaps exacerbated by altered mononuclear phagocyte system function in the setting of asplenia.
Q 热是一种不常见但可能报告不足的动物源传染病。严重的高铁蛋白血症与噬血细胞性淋巴组织细胞增生症和其他传染病有关。在本研究中，我们报告了一例脾切除患者合并严重高铁蛋白血症和骨髓浸润的贝纳柯克斯体感染。在这种情况下，显著的铁蛋白升高可能是由于 C 伯氏考克斯体对这种细胞类型的优先细胞内感染导致全身巨噬细胞激活的指标，脾切除后单核吞噬细胞系统功能改变可能使其加重。
