通过铜催化串联偶联/双环化反应一锅法合成吡咯并[3,2,1 - kl]吩噻嗪
One-Pot Synthesis of Pyrrolo[3,2,1-kl]phenothiazines through Copper-Catalyzed Tandem Coupling/Double Cyclization Reaction.
作者信息
Tang Jiaming, Xu Bingqing, Mao Xi, Yang Hongyan, Wang Xiaoxia, Lv Xin
机构信息
Department of Chemistry, College of Chemistry and Life Sciences, Zhejiang Normal University , Jinhua 321004, People's Republic of China.
出版信息
J Org Chem. 2015 Nov 6;80(21):11108-14. doi: 10.1021/acs.joc.5b01745. Epub 2015 Oct 9.
A novel and efficient synthesis of pyrrolo[3,2,1-kl]phenothiazines has been developed through a Cu(I)-catalyzed tandem C-S coupling/double cyclization process. Using 2-alkynyl-6-iodoanilines and o-bromobenzenethiols as the starting materials, a wide range of pyrrolo[3,2,1-kl]phenothiazine derivatives were facilely and efficiently generated in one pot under Cu(I) catalysis.
通过铜（I）催化的串联C-S偶联/双环化过程，已开发出一种新颖且高效的吡咯并[3,2,1 - kl]吩噻嗪合成方法。以2-炔基-6-碘苯胺和邻溴苯硫酚为起始原料，在铜（I）催化下，可在一锅反应中简便高效地生成多种吡咯并[3,2,1 - kl]吩噻嗪衍生物。
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