Key Laboratory of Eco-Environment-Related Polymer Materials Ministry of Education; College of Chemistry and Chemical Engineering, Northwest Normal University , Lanzhou, Gansu 730070, China.
Org Lett. 2015 Oct 16;17(20):5028-31. doi: 10.1021/acs.orglett.5b02504. Epub 2015 Oct 2.
A novel iron-catalyzed dual-oxidative dehydrogenative (DOD) tandem annulation of glycine derivatives with tetrahydrofurans (THFs) for the synthesis of high value quinoline fused lactones has been developed. The reactions were performed under mild reaction conditions. And the use of cheap substrates (glycine derivatives and THF) and an even cheaper simple inorganic iron salt as the catalyst makes this protocol very attractive for potential synthetic applications.
一种新型铁催化的甘氨酸衍生物与四氢呋喃（THF）的双重氧化脱氢（DOD）串联环化反应，用于合成高价值的喹啉稠合内酯，已经被开发出来。该反应在温和的反应条件下进行。而且，使用廉价的底物（甘氨酸衍生物和 THF）和更便宜的简单无机铁盐作为催化剂，使得该方案在潜在的合成应用中非常有吸引力。
