Chazan Bibiana, Raz Raul, Edelstein Hana, Kennes Yoram, Gal Vered, Colodner Raul
1 Infectious Diseases Unit, Emek Medical Center , Afula, Israel .
2 Rappaport Faculty of Medicine, Technion , Haifa, Israel .
Microb Drug Resist. 2015 Oct;21(5):551-5. doi: 10.1089/mdr.2015.0040. Epub 2015 Jun 2.
Resistant pathogens are an increasing threat affecting millions of people globally. More complicated patients are presented with pathogens harboring new resistance mechanisms, while the pipeline of new antimicrobials hardly proposes solutions. In such a scenario, more severely ill patients remain with no adequate treatment to offer. In addition, massive misuse of antimicrobials, including excessive length of treatment or wrong dosage, also contributes to increasing the rate of pathogens resistance to antimicrobials. Isolation of Streptococcus pyogenes (Group A Streptococcus-GAS) is the main indication for antibiotic treatment to patients diagnosed with acute tonsillitis. Hence, GAS resistance to antibiotics requires periodic monitoring.
To assess susceptibility rates of GAS to penicillin, macrolides, clindamycin, and tetracycline in northern Israel and to compare the findings to the high antimicrobial susceptibility of GAS isolates reported in the same region in 2004 and to other geographical areas.
Throat samples from 300 outpatients were collected and cultured at the regional laboratory of Emek Medical Center during September to October 2011.
In 300 samples, the susceptibility rates of GAS to penicillin, erythromycin, azithromycin, clindamycin, and tetracycline in northern Israel still remain very high.
Continuous control of antimicrobials usage and periodic surveillance of susceptibility rates, together with educational programs and appropriate and targeted treatment protocols, are essential and highly recommended to keep these high susceptibility rates for as long as possible.
耐药病原体对全球数百万人构成的威胁日益增加。越来越多病情复杂的患者感染了具有新耐药机制的病原体，而新型抗菌药物的研发进展却难以提供解决方案。在这种情况下，病情较重的患者仍然得不到充分的治疗。此外，抗菌药物的大量滥用，包括治疗时间过长或剂量错误，也导致病原体对抗菌药物的耐药率不断上升。化脓性链球菌（A组链球菌，GAS）的分离是诊断为急性扁桃体炎患者抗生素治疗的主要指征。因此，需要定期监测GAS对抗生素的耐药情况。
评估以色列北部GAS对青霉素、大环内酯类、克林霉素和四环素的药敏率，并将结果与2004年该地区报告的GAS分离株的高抗菌药敏率以及其他地理区域进行比较。
2011年9月至10月期间，在埃梅克医疗中心区域实验室收集了300名门诊患者的咽喉样本并进行培养。
在300份样本中，以色列北部GAS对青霉素、红霉素、阿奇霉素、克林霉素和四环素的药敏率仍然很高。
持续控制抗菌药物的使用并定期监测药敏率，同时开展教育项目以及制定适当且有针对性的治疗方案，对于尽可能长时间保持这些高药敏率至关重要，强烈推荐实施。
