Weiss I, Gorodnitzky Z, Korenman Z, Yagupsky P
Clinical Microbiology Laboratories, Soroka Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Eur J Clin Microbiol Infect Dis. 1997 Jan;16(1):20-3. doi: 10.1007/BF01575115.
Fifty-seven strains of Streptococcus pyogenes isolated from septic patients and 52 isolates from nonbacteremic patients in southern Israel were investigated for their susceptibility to new macrolides and other antimicrobial drugs. In addition, typing of the isolates by M protein and T antigen was performed. All organisms were susceptible to penicillin and chloramphenicol, 59% to tetracycline, and 7% to trimethoprim-sulfamethoxazole. All isolates but one (99%) were susceptible to clarithromycin, azithromycin, erythromycin, and clindamycin. The MIC90 of clarithromycin, erythromycin, and clindamycin was 0.064, 0.125, and 0.094 microgram/ml, respectively. Overall, 96% of the isolates could be typed by T antigen, but only 43% were M-protein typeable. No predominance of any particular M-protein type was observed. No significant differences between blood isolates and organisms derived from other sources were observed in the antibiotic susceptibility patterns or the distribution of serotypes. It is concluded that invasive Streptococcus pyogenes infections in southern Israel are caused by multiple unrelated strains. The organism remains susceptible to macrolides and clindamycin.
对从以色列南部败血症患者中分离出的57株化脓性链球菌以及从非菌血症患者中分离出的52株菌株进行了研究，以检测它们对新型大环内酯类药物和其他抗菌药物的敏感性。此外，还对分离株进行了M蛋白和T抗原分型。所有菌株对青霉素和氯霉素敏感，59%对四环素敏感，7%对甲氧苄啶-磺胺甲恶唑敏感。除1株外（99%），所有分离株对克拉霉素、阿奇霉素、红霉素和克林霉素敏感。克拉霉素、红霉素和克林霉素的MIC90分别为0.064、0.125和0.094微克/毫升。总体而言，96%的分离株可通过T抗原分型，但只有43%可进行M蛋白分型。未观察到任何特定M蛋白类型占优势。在抗生素敏感性模式或血清型分布方面，血液分离株与其他来源的菌株之间未观察到显著差异。得出的结论是，以色列南部侵袭性化脓性链球菌感染是由多种不相关菌株引起的。该菌对大环内酯类药物和克林霉素仍然敏感。
