Imöhl Matthias, van der Linden Mark
Institute of Medical Microbiology and National Reference Center for Streptococci, University Hospital RWTH Aachen, Aachen, Germany.
PLoS One. 2015 Sep 4;10(9):e0137313. doi: 10.1371/journal.pone.0137313. eCollection 2015.
A nationwide laboratory-based surveillance study of invasive S. pyogenes infections was conducted in Germany. Invasive isolates (n = 1,281) were obtained between 2003 and 2013. All isolates were susceptible to penicillin, cefotaxime and vancomycin. Tetracycline showed the highest rate of resistant or intermediate resistant isolates with 9.8%, followed by macrolides (4.0%), trimethoprim/sulfamethoxazole (SXT) (1.9%), levofloxacin (1.3%), chloramphenicol (0.9%) and clindamycin (0.7%). The most prominent trends were the appearance of levofloxacin non-susceptible isolates since 2011, and an increase of SXT non-susceptibility since 2012.
在德国开展了一项基于实验室的全国性侵袭性酿脓链球菌感染监测研究。在2003年至2013年期间获取了侵袭性分离株（n = 1281）。所有分离株对青霉素、头孢噻肟和万古霉素敏感。四环素耐药或中介耐药分离株的比例最高，为9.8%，其次是大环内酯类（4.0%）、甲氧苄啶/磺胺甲恶唑（SXT）（1.9%）、左氧氟沙星（1.3%）、氯霉素（0.9%）和克林霉素（0.7%）。最显著的趋势是自2011年以来出现了左氧氟沙星不敏感分离株，以及自2012年以来SXT不敏感性增加。
