i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal; Cancer Drug Resistance Group, Institute of Molecular Pathology and Immunology of the University of Porto, IPATIMUP, 4200-135 Porto, Portugal; Department of Biological Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.
i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal; Cancer Drug Resistance Group, Institute of Molecular Pathology and Immunology of the University of Porto, IPATIMUP, 4200-135 Porto, Portugal; Department of Pathology and Oncology, Faculty of Medicine of the University of Porto, 4200-319 Porto, Portugal.
Trends Mol Med. 2015 Oct;21(10):595-608. doi: 10.1016/j.molmed.2015.08.002.
Extracellular vesicles (EVs) are nanosized particles (100-1000 nm) enclosed by a phospholipid bilayer that have been described as important mediators of intercellular communication. The role of EVs in oncobiology has been extensively studied, including their contribution to the horizontal transfer of drug resistance from drug-resistant to drug-sensitive cancer cells. This review focuses on the EVs cargo responsible for this intercellular transfer of drug resistance; namely, drug-efflux pumps, miRNAs, long noncoding RNAs (lncRNAs), and other mediators. Additionally, the known molecular mechanisms and features of this transfer are discussed. This is an emerging area of research and we highlight topics that need to be further studied to fully understand and counteract the intercellular transfer of drug resistance mediated by EVs.
细胞外囊泡 (EVs) 是一种纳米级颗粒 (100-1000nm)，由磷脂双层包裹，被描述为细胞间通讯的重要介质。EVs 在肿瘤生物学中的作用已经得到了广泛的研究，包括它们在耐药性从耐药癌细胞到敏感癌细胞的水平转移中的作用。本综述重点介绍了负责这种细胞间耐药性转移的 EVs 货物; 即，药物外排泵、miRNAs、长非编码 RNA (lncRNAs) 和其他介质。此外，还讨论了这种转移的已知分子机制和特征。这是一个新兴的研究领域，我们强调了需要进一步研究的主题，以充分理解和对抗 EVs 介导的细胞间耐药性转移。
