血清25-羟维生素D水平与年龄相关性白内障之间的关联。
Association between serum 25-hydroxyvitamin D levels and age-related cataracts.
作者信息
Jee Donghyun, Kim Eun Chul
机构信息
From the Department of Ophthalmology and Visual Science (Jee), St. Vincent's Hospital, College of Medicine, Catholic University of Korea, Suwon, Gyenggido, and the Department of Ophthalmology and Visual Science (Kim), Bucheon St. Mary's Hospital, College of Medicine, Catholic University of Korea, Bucheon, Gyeonggido, South Korea.
From the Department of Ophthalmology and Visual Science (Jee), St. Vincent's Hospital, College of Medicine, Catholic University of Korea, Suwon, Gyenggido, and the Department of Ophthalmology and Visual Science (Kim), Bucheon St. Mary's Hospital, College of Medicine, Catholic University of Korea, Bucheon, Gyeonggido, South Korea.
出版信息
J Cataract Refract Surg. 2015 Aug;41(8):1705-15. doi: 10.1016/j.jcrs.2014.12.052.
PURPOSE
To investigate associations between serum 25-hydroxyvitamin D levels and age-related cataracts.
SETTING
Department of Ophthalmology, College of Medicine, Catholic University of Korea, South Korea.
DESIGN
Observational cross-sectional study.
METHODS
Participants aged 40 years or older in the fourth (2008 to 2009) and fifth (2010 to 2012) Korea National Health and Nutrition Examination Survey (KNHANES) had evaluation of their serum 25-hydroxyvitamin D levels and ophthalmic slitlamp examinations to identify cataract. An age-related cataract was defined as the presence of a cortical, nuclear, anterior subcapsular, posterior subcapsular, or mixed cataract or a history of cataract surgery.
RESULTS
The study evaluated eyes of 18 804 patients. The mean levels of serum 25-hydroxyvitamin D were 20.0 ng/mL in men and 17.5 ng/mL in women. In men, but not in women, the odds ratio (OR) for age-related cataracts decreased statistically significantly when the serum 25-hydroxyvitamin D levels were in the highest quintile than when they were in the lowest quintile (OR, 0.76; 95% confidence interval, 0.59-0.99) after adjusting for potentially confounding factors including age, sex, smoking status, diabetes, hypertension, and sunlight exposure. However, trend analysis did not show a significant declining trend in the cataract risk associated with higher serum 25-hydroxyvitamin D quintiles (P = .084). In women, serum 25-hydroxyvitamin D levels were not associated with age-related cataracts.
CONCLUSIONS
The age-related cataract risk decreased in men with higher serum 25-hydroxyvitamin D levels than in those with lower serum 25-hydroxyvitamin D levels after adjusting for potential confounding factors. In light of previous research indicating an antioxidative effect of vitamin D, the connection between vitamin D and age-related cataract warrants further study.
FINANCIAL DISCLOSURE
Neither author has a financial or proprietary interest in any material or method mentioned.
目的
探讨血清25-羟基维生素D水平与年龄相关性白内障之间的关联。
研究地点
韩国天主教大学医学院眼科。
研究设计
观察性横断面研究。
方法
在韩国第四次（2008年至2009年）和第五次（2010年至2012年）全国健康与营养检查调查（KNHANES）中，对40岁及以上的参与者进行血清25-羟基维生素D水平评估和眼科裂隙灯检查以确定白内障。年龄相关性白内障定义为存在皮质性、核性、前囊下、后囊下或混合性白内障或有白内障手术史。
结果
该研究评估了18804例患者的眼睛。男性血清25-羟基维生素D的平均水平为20.0 ng/mL，女性为17.5 ng/mL。在男性中，而非女性中，在调整了包括年龄、性别、吸烟状况、糖尿病、高血压和阳光暴露等潜在混杂因素后，当血清25-羟基维生素D水平处于最高五分位数时，年龄相关性白内障的优势比（OR）相较于处于最低五分位数时在统计学上显著降低（OR，0.76；95%置信区间，0.59 - 0.99）。然而，趋势分析未显示与较高血清25-羟基维生素D五分位数相关的白内障风险有显著下降趋势（P = 0.084）。在女性中，血清25-羟基维生素D水平与年龄相关性白内障无关。
结论
在调整潜在混杂因素后，血清25-羟基维生素D水平较高的男性与较低的男性相比，年龄相关性白内障风险降低。鉴于先前研究表明维生素D具有抗氧化作用，维生素D与年龄相关性白内障之间的联系值得进一步研究。
财务披露
两位作者均对文中提及的任何材料或方法没有财务或专利权益。
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