这能有多复杂？载脂蛋白L1风险变异与肾脏和心血管疾病中脂蛋白异质性之间的联系。
How complicated can it be? The link between APOL1 risk variants and lipoprotein heterogeneity in kidney and cardiovascular diseases.
作者信息
Hu Chien-An A, Ray Patricio E
机构信息
Department of Biochemistry and Molecular Biology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
Children's National Medical Center, Department of Pediatrics, The George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
出版信息
Nephrol Dial Transplant. 2016 Apr;31(4):509-11. doi: 10.1093/ndt/gfv357. Epub 2015 Oct 3.
Abstract
….the findings of Gutierrez et al. (22) add more fuel to the ongoing controversy regarding the association of APOL1 G1/G2 risk status with cardiovascular outcome among African Americans. However, if we acknowledge that the APOL1 risk alleles may directly modify the circulating levels of small HDL and/or other factors and induce a proatherogenic state that precipitates CKD and cardiovascular complications, then we should begin to answer several questions ….
摘要
古铁雷斯等人（22）的研究结果，为非裔美国人中载脂蛋白L1（APOL1）G1/G2风险状态与心血管结局之间关联的持续争议增添了更多的论据。然而，如果我们承认APOL1风险等位基因可能直接改变小高密度脂蛋白（HDL）的循环水平和/或其他因素，并诱发促动脉粥样硬化状态，进而引发慢性肾脏病（CKD）和心血管并发症，那么我们就应该开始回答几个问题……
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