Zakkouri Fatima Az-zahra, Saloua Ouaouch, Halima Abahssain, Rachid Razine, Hind Mrabti, Hassan Errihani
Department of Medical Oncology, National Institute of Oncology, Rabat, Morocco.
Department of medical oncology, National Institute of Oncology, Agdal/Riad, 10000, Rabat, Morocco.
BMC Res Notes. 2015 Oct 3;8:530. doi: 10.1186/s13104-015-1503-3.
Recently women's lung cancer mortality rates have dramatically increased in developed countries, contrasting with a levelling off or decrease among men. Descriptive epidemiological data on primary lung cancer in women is scarce in Morocco. The aim of this study, conducted in the National Institute of Oncology in Rabat, was to describe the epidemiological profiling especially for the smoking status, to determine the most frequent type of lung cancer, and to analyse the survival of Moroccan women with lung cancer diagnosis.
We found 101 women among 1680 (male and female) cases of lung cancer. The never-smokers were estimated to 75 %. The proportion of adenocarcinoma among never and passive smokers was higher than that of squamous cell carcinoma (SCC) (69.4 versus 30.6 %), while among women who were smokers, the most frequent histological type was SCC (63.6 %). The Cox regression analysis showed that smoking and passive smoking were not significantly associated with survival [HR: 0.62 (95 % CI 0.31, 1.30); p = 0.19] [HR: 0.56 (95 % CI 0.29, 1.08); p = 0.08] respectively. Adenocarcinoma was significantly associated with shorter survival [HR: 1.73 (95 % CI 1.05, 2.85); p = 0.03].
The majority Moroccan women affected by lung cancer have never smoked (75 %). Environmental exposures, genetic predisposition, hormonal factors, and viral infection may all play a role in lung cancer in this category. The relation between histological type and tobacco found in our series concurred with those reported in the literature--adenocarcinoma appears to be the most frequent cell type affecting never and passive smokers. Adenocarcinoma is significantly associated with poorer survival.
最近，发达国家女性肺癌死亡率急剧上升，而男性肺癌死亡率则趋于平稳或下降。摩洛哥缺乏关于女性原发性肺癌的描述性流行病学数据。本研究在拉巴特国家肿瘤研究所开展，旨在描述流行病学概况，尤其是吸烟状况，确定最常见的肺癌类型，并分析摩洛哥肺癌确诊女性的生存率。
我们在1680例（男性和女性）肺癌病例中发现了101名女性。从不吸烟者估计占75%。在从不吸烟者和被动吸烟者中，腺癌的比例高于鳞状细胞癌（SCC）（69.4%对30.6%），而在吸烟女性中，最常见的组织学类型是SCC（63.6%）。Cox回归分析表明，吸烟和被动吸烟与生存率均无显著关联[风险比（HR）：0.62（95%置信区间0.31，1.30）；p = 0.19] [HR：0.56（95%置信区间0.29，1.08）；p = 0.08]。腺癌与较短生存期显著相关[HR：1.73（95%置信区间1.05，2.85）；p = 0.03]。
大多数患肺癌的摩洛哥女性从不吸烟（75%）。环境暴露、遗传易感性、激素因素和病毒感染可能在这类肺癌中均起作用。我们系列研究中发现的组织学类型与烟草之间的关系与文献报道一致——腺癌似乎是影响从不吸烟者和被动吸烟者的最常见细胞类型。腺癌与较差的生存率显著相关。
