Wang Kun, Li Ling, Wu Yang, Yang Yu, Chen Jie, Zhang Danyu, Liu Zhoujun, Xu Juan, Cao Meng, Mao Xiaodong, Liu Chao
Department of Endocrinology, Affiliated Hospital on Integration of Chinese and Western Medicine, Nanjing University of Chinese Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, 100, Hongshan Road, Nanjing, 210028, China.
Department of Endocrinology, Zhongda Hospital, School of Medicine, Southeast University, 87, Dingjiaqiao Road, Nanjing, 210009, China.
Endocrine. 2016 Apr;52(1):63-72. doi: 10.1007/s12020-015-0760-1. Epub 2015 Oct 3.
The purpose of our study is to examine the association between serum GGT levels and ventricular instability in Chinese patients with T2DM. We conducted a cross-sectional, community-based study in Nanjing, China from June to November 2011. Among 10,050 patients aged 40-79 years, we enrolled 2444 with pre-diabetes, 2496 with T2DM, and 4521 without diabetes (non-diabetes). Electrocardiograms were performed to measure the QT interval corrected for heart rate (QTc) and QT interval dispersion (QTd). Serum GGT levels, metabolic parameters, body mass index, and blood pressure were also measured. We found that there were no significant associations of increased QTc/QTd with serum GGT levels in participants with pre-existing T2DM and non-diabetes, after adjusting for age, duration of diabetes, and metabolic parameters. Even after adjustment, higher risks of QTc ≥ 440 ms/√s and QTd ≥ 58 ms were found in participants with serum GGT levels ≥49 U/L compared with those with <15 U/L in the pre-diabetes (QTc: OR 1.96, 95 % CI 1.23-2.47; QTd: OR 1.34, 95 % CI 1.07-1.94) and newly diagnosed T2DM (QTc: OR 2.01, 95 % CI 1.39-2.51; QTd: OR 1.53, 95 % CI 1.03-1.99) groups. We conclude that Increased serum GGT levels are associated with some markers of ventricular repolarization abnormalities in the early stage of T2DM.
我们研究的目的是探讨中国2型糖尿病患者血清γ-谷氨酰转移酶（GGT）水平与心室不稳定性之间的关联。2011年6月至11月，我们在中国南京开展了一项基于社区的横断面研究。在10050名年龄在40 - 79岁的患者中，我们纳入了2444名糖尿病前期患者、2496名2型糖尿病患者和4521名无糖尿病患者（非糖尿病组）。进行心电图检查以测量校正心率后的QT间期（QTc）和QT间期离散度（QTd）。同时还测量了血清GGT水平、代谢参数、体重指数和血压。我们发现，在调整年龄、糖尿病病程和代谢参数后，已患2型糖尿病和非糖尿病参与者的QTc/QTd升高与血清GGT水平之间无显著关联。即使经过调整，与血清GGT水平<15 U/L的参与者相比，血清GGT水平≥49 U/L的糖尿病前期参与者（QTc：比值比[OR] 1.96，95%置信区间[CI] 1.23 - 2.47；QTd：OR 1.34，95% CI 1.07 - 1.94）和新诊断的2型糖尿病参与者（QTc：OR 2.01，95% CI 1.39 - 2.51；QTd：OR 1.53，95% CI 1.03 - 1.99）发生QTc≥440 ms/√s和QTd≥58 ms的风险更高。我们得出结论，血清GGT水平升高与2型糖尿病早期心室复极异常的某些标志物相关。
