Zhang Yan, Ma Hang, Yuan Tao, Seeram Navindra P
Nat Prod Commun. 2015 Aug;10(8):1409-12.
The bark and stems of red maple (Acer rubrum) are reported to contain bioactive phenolics but its aerial parts, namely, flowers and leaves, remain largely unexplored. This is unfortunate considering that various parts of the red maple were used for traditional medicinal purposes by the indigenous peoples of eastern North America, where this species is found. Herein, we report the identification of twenty-five (1-25) phenolics, including two new galloyl derivatives (1 and 2), from red maple flowers and leaves. Of these, ten compounds (1-10), including the new compounds, were isolated and identified by NMR and HRESIMS data while the remaining fifteen compounds (11-25) were identified by HPLC-DAD analyses (by comparison with chemical standards). The isolates (1-10), along with the clinical drug, acarbose, were evaluated for their alpha-glucosidase enzyme inhibitory activities.
据报道，红枫（Acer rubrum）的树皮和茎含有生物活性酚类物质，但其地上部分，即花和叶，在很大程度上仍未得到充分研究。考虑到北美东部发现该物种的原住民将红枫的各个部分用于传统药用目的，这是很遗憾的。在此，我们报告从红枫花和叶中鉴定出25种（1 - 25）酚类物质，包括两种新的没食子酰衍生物（1和2）。其中，通过核磁共振（NMR）和高分辨电喷雾电离质谱（HRESIMS）数据分离并鉴定了10种化合物（1 - 10），包括新化合物，而其余15种化合物（11 - 25）通过高效液相色谱 - 二极管阵列检测（HPLC - DAD）分析（与化学标准品比较）进行鉴定。对分离出的化合物（1 - 10）以及临床药物阿卡波糖进行了α - 葡萄糖苷酶抑制活性评估。
