S100蛋白及其受体RAGE在胰腺癌中的作用。
The role of S100 proteins and their receptor RAGE in pancreatic cancer.
作者信息
Leclerc Estelle, Vetter Stefan W
机构信息
Department of Pharmaceutical Sciences, North Dakota State University, PO Box 6050, Department 2665, Fargo, ND 58108-6050, USA.
Department of Pharmaceutical Sciences, North Dakota State University, PO Box 6050, Department 2665, Fargo, ND 58108-6050, USA.
出版信息
Biochim Biophys Acta. 2015 Dec;1852(12):2706-11. doi: 10.1016/j.bbadis.2015.09.022. Epub 2015 Oct 3.
Abstract
Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with low survival rates. Current therapeutic treatments have very poor response rates due to the high inherent chemoresistance of the pancreatic-cancer cells. Recent studies have suggested that the receptor for advanced glycation end products (RAGE) and its S100 protein ligands play important roles in the progression of PDAC. We will discuss the potential role of S100 proteins and their receptor, RAGE, in the development and progression of pancreatic cancer.
摘要
胰腺导管腺癌（PDAC）是一种生存率很低的毁灭性疾病。由于胰腺癌细胞固有的高化学抗性，目前的治疗方法反应率非常低。最近的研究表明，晚期糖基化终产物受体（RAGE）及其S100蛋白配体在PDAC的进展中起重要作用。我们将讨论S100蛋白及其受体RAGE在胰腺癌发生和发展中的潜在作用。
相似文献
1
The role of S100 proteins and their receptor RAGE in pancreatic cancer.S100蛋白及其受体RAGE在胰腺癌中的作用。
Biochim Biophys Acta. 2015 Dec;1852(12):2706-11. doi: 10.1016/j.bbadis.2015.09.022. Epub 2015 Oct 3.
2
RAGE maintains high levels of NFκB and oncogenic Kras activity in pancreatic cancer.RAGE在胰腺癌中维持高水平的NFκB和致癌性Kras活性。
Biochem Biophys Res Commun. 2017 Nov 4;493(1):592-597. doi: 10.1016/j.bbrc.2017.08.147. Epub 2017 Sep 1.
3
HMGB1, S100 proteins and other RAGE ligands in cancer - markers, mediators and putative therapeutic targets.癌症中的HMGB1、S100蛋白及其他RAGE配体——标志物、介质及潜在治疗靶点
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2016 Mar;160(1):1-10. doi: 10.5507/bp.2016.003. Epub 2016 Feb 3.
4
S100 family signaling network and related proteins in pancreatic cancer (Review).S100 家族信号网络及其相关蛋白在胰腺癌中的作用（综述）。
Int J Mol Med. 2014 Apr;33(4):769-76. doi: 10.3892/ijmm.2014.1633. Epub 2014 Jan 24.
5
RAGE and S100 protein transcription levels are highly variable in human melanoma tumors and cells.RAGE和S100蛋白的转录水平在人类黑色素瘤肿瘤和细胞中高度可变。
Gen Physiol Biophys. 2009;28 Spec No Focus:F65-75.
6
The receptor for advanced glycation end products influences the expression of its S100 protein ligands in melanoma tumors.晚期糖基化终末产物受体影响黑色素瘤肿瘤中其S100蛋白配体的表达。
Int J Biochem Cell Biol. 2014 Dec;57:54-62. doi: 10.1016/j.biocel.2014.10.001. Epub 2014 Oct 13.
7
RAGE and its ligands in cancer - culprits, biomarkers, or therapeutic targets?癌症中的RAGE及其配体——罪魁祸首、生物标志物还是治疗靶点？
Neoplasma. 2015;62(3):353-64. doi: 10.4149/neo_2015_061.
8
Receptor for advanced glycation end products (RAGE) in vascular and inflammatory diseases.晚期糖基化终产物受体（RAGE）在血管和炎症性疾病中的作用。
Int J Cardiol. 2013 Oct 3;168(3):1788-94. doi: 10.1016/j.ijcard.2013.05.013. Epub 2013 May 27.
9
Interaction of S100A13 with C2 domain of receptor for advanced glycation end products (RAGE).S100A13与晚期糖基化终产物受体（RAGE）的C2结构域的相互作用。
Biochim Biophys Acta. 2014 Sep;1844(9):1718-28. doi: 10.1016/j.bbapap.2014.06.017. Epub 2014 Jun 28.
10
Receptor for advanced glycation end products (RAGE)-expressing endothelial cells co-express AGE and S100 in human periapical granulomas.表达晚期糖基化终产物受体（RAGE）的内皮细胞在人根尖肉芽肿中共同表达 AGE 和 S100。
J Dent. 2011 Oct;39(10):679-85. doi: 10.1016/j.jdent.2011.07.010. Epub 2011 Aug 16.
引用本文的文献
1
Relationship of S100 Proteins with Neuroinflammation.S100蛋白与神经炎症的关系。
Biomolecules. 2025 Aug 4;15(8):1125. doi: 10.3390/biom15081125.
2
Interpretable machine learning-guided single-cell mapping deciphers multi-lineage pancreatic dysregulation in type 2 diabetes.可解释的机器学习引导的单细胞图谱解析2型糖尿病中多谱系胰腺失调。
Cardiovasc Diabetol. 2025 Jul 24;24(1):300. doi: 10.1186/s12933-025-02865-8.
3
Immune Subtypes and Characteristics of Endometrial Cancer Based on Immunogenes.基于免疫基因的子宫内膜癌免疫亚型及特征
Cancer Manag Res. 2024 Oct 29;16:1525-1543. doi: 10.2147/CMAR.S494838. eCollection 2024.
4
Role of Receptor for Advanced Glycation End-Products in Endometrial Cancer: A Review.晚期糖基化终末产物受体在子宫内膜癌中的作用：综述
Cancers (Basel). 2024 Sep 19;16(18):3192. doi: 10.3390/cancers16183192.
5
An mRNA vaccine for pancreatic cancer designed by applying in silico immunoinformatics and reverse vaccinology approaches.一种应用计算机免疫信息学和反向疫苗学方法设计的胰腺癌 mRNA 疫苗。
PLoS One. 2024 Jul 8;19(7):e0305413. doi: 10.1371/journal.pone.0305413. eCollection 2024.
6
S100 calcium‑binding protein A16 suppresses the osteogenic differentiation of rat bone marrow mesenchymal stem cells by inhibiting SMAD family member 4 signaling.S100钙结合蛋白A16通过抑制SMAD家族成员4信号传导来抑制大鼠骨髓间充质干细胞的成骨分化。
Exp Ther Med. 2024 Apr 15;27(6):250. doi: 10.3892/etm.2024.12538. eCollection 2024 Jun.
7
Correlation between S100A7 and immune characteristics, methylation, tumor stemness and tumor heterogeneity in pan-cancer and its role in chemotherapy resistance in breast cancer.S100A7 在泛癌中的免疫特征、甲基化、肿瘤干性和肿瘤异质性的相关性及其在乳腺癌化疗耐药中的作用。
Aging (Albany NY). 2024 Mar 18;16(6):5581-5600. doi: 10.18632/aging.205665.
8
Soluble Receptor for Advanced Glycation End Products (sRAGE) Level and Its Prognostic Significance in Children with Acute Lymphoblastic Leukemia.晚期糖基化终末产物可溶性受体（sRAGE）水平及其在儿童急性淋巴细胞白血病中的预后意义
Children (Basel). 2024 Jan 31;11(2):176. doi: 10.3390/children11020176.
9
Novel piperazine-1,2,3-triazole leads for the potential treatment of pancreatic cancer.用于潜在治疗胰腺癌的新型哌嗪-1,2,3-三唑先导化合物。
RSC Med Chem. 2023 Jul 5;14(11):2246-2267. doi: 10.1039/d2md00289b. eCollection 2023 Nov 15.
10
CD74 Promotes a Pro-Inflammatory Tumor Microenvironment by Inducing S100A8 and S100A9 Secretion in Pancreatic Cancer.CD74 通过诱导胰腺癌中 S100A8 和 S100A9 的分泌促进促炎肿瘤微环境。
Int J Mol Sci. 2023 Aug 20;24(16):12993. doi: 10.3390/ijms241612993.
本文引用的文献
1
S100 calcium-binding protein A6 promotes epithelial-mesenchymal transition through β-catenin in pancreatic cancer cell line.S100钙结合蛋白A6通过β-连环蛋白促进胰腺癌细胞系的上皮-间质转化。
PLoS One. 2015 Mar 23;10(3):e0121319. doi: 10.1371/journal.pone.0121319. eCollection 2015.
2
S100A4 promotes pancreatic cancer progression through a dual signaling pathway mediated by Src and focal adhesion kinase.S100A4通过由Src和粘着斑激酶介导的双信号通路促进胰腺癌进展。
Sci Rep. 2015 Feb 13;5:8453. doi: 10.1038/srep08453.
3
S100 proteins in cancer.癌症中的S100蛋白
Nat Rev Cancer. 2015 Feb;15(2):96-109. doi: 10.1038/nrc3893.
4
Pancreatic ductal adenocarcinoma: From genetics to biology to radiobiology to oncoimmunology and all the way back to the clinic.胰腺导管腺癌：从遗传学到生物学，再到放射生物学、肿瘤免疫学，最后回归临床。
Biochim Biophys Acta. 2015 Jan;1855(1):61-82. doi: 10.1016/j.bbcan.2014.12.001. Epub 2014 Dec 7.
5
Interaction between S100P and the anti-allergy drug cromolyn.S100P与抗过敏药物色甘酸钠之间的相互作用。
Biochem Biophys Res Commun. 2014 Nov 21;454(3):404-9. doi: 10.1016/j.bbrc.2014.10.048. Epub 2014 Oct 17.
6
S100A6 is secreted from Wharton's jelly mesenchymal stem cells and interacts with integrin β1.S100A6由华通氏胶间充质干细胞分泌，并与整合素β1相互作用。
Int J Biochem Cell Biol. 2014 Oct;55:298-303. doi: 10.1016/j.biocel.2014.09.015. Epub 2014 Sep 22.
7
Diagnostic value of S100P for pancreatic cancer: a meta-analysis.S100P对胰腺癌的诊断价值：一项荟萃分析。
Tumour Biol. 2014 Oct;35(10):9479-85. doi: 10.1007/s13277-014-2461-4. Epub 2014 Aug 15.
8
Structural insights into calcium-bound S100P and the V domain of the RAGE complex.钙结合型S100P与RAGE复合物V结构域的结构解析。
PLoS One. 2014 Aug 1;9(8):e103947. doi: 10.1371/journal.pone.0103947. eCollection 2014.
9
Sonic hedgehog-Gli1 signaling pathway regulates the epithelial mesenchymal transition (EMT) by mediating a new target gene, S100A4, in pancreatic cancer cells.音猬因子-Gli1信号通路通过介导胰腺癌细胞中的一个新靶基因S100A4来调节上皮-间质转化（EMT）。
PLoS One. 2014 Jul 29;9(7):e96441. doi: 10.1371/journal.pone.0096441. eCollection 2014.
10
Expression of KOC, S100P, mesothelin and MUC1 in pancreatico-biliary adenocarcinomas: development and utility of a potential diagnostic immunohistochemistry panel.KOC、S100P、间皮素和MUC1在胰胆管腺癌中的表达：一种潜在诊断性免疫组织化学检测组合的开发与应用
BMC Clin Pathol. 2014 Jul 23;14:35. doi: 10.1186/1472-6890-14-35. eCollection 2014.
Zotero 插件