Bartel H, Piatowska D
Oral Surg Oral Med Oral Pathol. 1977 Jan;43(1):82-96. doi: 10.1016/0030-4220(77)90354-1.
Six giant-cell tumors have been examined by electron microscopic methods in order to determine their histogenesis and to expand knowledge of cell structures. The examination of giant cells revealed an abundance of cell organelles, especially mitochondria. Apart from typical stromal cells, such as fibroblasts, macrophages, and mast cells, clusters of stromal "light" cells were often found with an intimate relation between their cell membranes. The role and function of these cells is not well known. Between fibroblasts of regular appearance with a small number of cytoplasmic organelles, others were found with an incrased number of mitochondria. These cells often formed aggregates. This suggests that giant cells develop through the association of stroma fibroblast cells.
为了确定其组织发生并拓展对细胞结构的认识，已采用电子显微镜方法对六个骨巨细胞瘤进行了检查。巨细胞检查显示有大量细胞器，尤其是线粒体。除了典型的基质细胞，如成纤维细胞、巨噬细胞和肥大细胞外，还经常发现基质“亮”细胞簇，它们的细胞膜之间关系密切。这些细胞的作用和功能尚不清楚。在具有少量细胞质细胞器的正常外观成纤维细胞之间，发现了其他线粒体数量增加的细胞。这些细胞常形成聚集体。这表明巨细胞是通过基质成纤维细胞的联合发育而来。
