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Prevalence and distribution of intervertebral disc degeneration over the entire spine in a population-based cohort: the Wakayama Spine Study.基于人群的脊柱研究：整个脊柱中椎间盘退变的流行率和分布：和歌山脊柱研究。
Osteoarthritis Cartilage. 2014 Jan;22(1):104-10. doi: 10.1016/j.joca.2013.10.019. Epub 2013 Nov 14.
2
Prevalence and sex difference of lumbar disc space narrowing in elderly chinese men and women: osteoporotic fractures in men (Hong Kong) and osteoporotic fractures in women (Hong Kong) studies.中国老年男性和女性腰椎间盘间隙变窄的患病率及性别差异：男性骨质疏松性骨折（香港）和女性骨质疏松性骨折（香港）研究
Arthritis Rheum. 2013 Apr;65(4):1004-10. doi: 10.1002/art.37857.
3
[Incidence of Modic degenerative changes in patients with chronic lumbar pain at Monterrey Regional ISSSTE Hospital].[蒙特雷地区ISSSTE医院慢性腰痛患者中Modic退变改变的发生率]
Acta Ortop Mex. 2012 May-Jun;26(3):180-4.
4
Modic type I changes and recovery of back pain after lumbar microdiscectomy.腰椎间盘切除术后 Modic Ⅰ型改变与腰痛的恢复。
Eur Spine J. 2012 Nov;21(11):2252-8. doi: 10.1007/s00586-012-2419-4. Epub 2012 Jul 29.
5
Is the development of Modic changes associated with clinical symptoms? A 14-month cohort study with MRI.Modic 改变的发展与临床症状有关吗？一项为期 14 个月的 MRI 队列研究。
Eur Spine J. 2012 Nov;21(11):2271-9. doi: 10.1007/s00586-012-2309-9. Epub 2012 Apr 24.
6
Are Modic changes prognostic for recovery in a cohort of patients with non-specific low back pain?Modic 改变是否预示着非特异性腰痛患者队列的恢复？
Eur Spine J. 2012 Mar;21(3):418-24. doi: 10.1007/s00586-011-1964-6. Epub 2011 Aug 12.
7
Menopause causes vertebral endplate degeneration and decrease in nutrient diffusion to the intervertebral discs.绝经导致椎体终板退变和椎间盘营养扩散减少。
Med Hypotheses. 2011 Jul;77(1):18-20. doi: 10.1016/j.mehy.2011.03.014. Epub 2011 Mar 26.
8
Vertebral endplate signal changes (Modic change): a systematic literature review of prevalence and association with non-specific low back pain.椎体终板信号改变（Modic改变）：关于患病率及其与非特异性下腰痛相关性的系统文献综述
Eur Spine J. 2008 Nov;17(11):1407-22. doi: 10.1007/s00586-008-0770-2. Epub 2008 Sep 12.
9
Modic changes: a systematic review of the literature.Modic改变：文献的系统评价
Eur Spine J. 2008 Oct;17(10):1289-99. doi: 10.1007/s00586-008-0758-y. Epub 2008 Aug 27.
10
Intra- and interobserver reproducibility of vertebral endplate signal (modic) changes in the lumbar spine: the Nordic Modic Consensus Group classification.腰椎椎体终板信号（Modic）改变的观察者内和观察者间可重复性：北欧Modic共识组分类
Acta Radiol. 2007 Sep;48(7):748-54. doi: 10.1080/02841850701422112.

腰椎不稳患者椎体终板Modic改变的发生率及其对手术疗效的影响。

Frequency of Vertebral Endplate Modic Changes in Patients with Unstable Lumbar Spine and Its Effect on Surgical Outcome.

作者信息

Ghodsi Seyyed Mohammad, Rouhani Reza, Abdollahzade Sina, Khadivi Masoud, Faghih Jouibari Morteza

机构信息

Department of Neurosurgery, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.

出版信息

Asian Spine J. 2015 Oct;9(5):737-40. doi: 10.4184/asj.2015.9.5.737. Epub 2015 Sep 22.

DOI:10.4184/asj.2015.9.5.737
PMID:26435792
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4591445/
Abstract

STUDY DESIGN

Prospective cohort study.

PURPOSE

In this study, we investigated the frequency of vertebral endplate Modic changes (MCs) and their effects on surgical outcomes in patients with unstable lumbar spines.

OVERVIEW OF LITERATURE

Signal changes in endplates have been classified into three types by Modic. The prognostic role of MCs has been investigated in various spinal disorders.

METHODS

A series of 70 patients with clinical and radiographic unstable lumbar spine were included in the study. Endplate signal intensity was determined according to Modic classification. All patients underwent instrumented posterolateral fusion. Functional evaluation was made using the visual analog scale (VAS) and Oswestry disability index (ODI).

RESULTS

Eighteen patients (26%) had normal endplate intensity, 31 patients (44%) had MC type I, 20 patients (28%) had MC type II, and one patient (1.4%) had MC type III. Pain level VAS and ODI decreased significantly from the preoperative evaluation to the six-month and one-year postoperative evaluations. The surgical outcome (VAS and ODI) was not significantly different between the various types of MC.

CONCLUSIONS

Posterolateral fusion is an effective treatment in patients with unstable lumbar spines. MC do not have a significant effect on the surgical outcome of these patients.

摘要

研究设计

前瞻性队列研究。

目的

在本研究中，我们调查了不稳定腰椎患者椎体终板Modic改变（MCs）的发生率及其对手术结果的影响。

文献综述

终板信号改变已被Modic分为三种类型。MCs在各种脊柱疾病中的预后作用已得到研究。

方法

本研究纳入了一系列70例临床和影像学检查显示腰椎不稳定的患者。根据Modic分类确定终板信号强度。所有患者均接受了后路器械融合术。使用视觉模拟量表（VAS）和Oswestry功能障碍指数（ODI）进行功能评估。

结果

18例患者（26%）终板强度正常，31例患者（44%）为I型MC，20例患者（28%）为II型MC，1例患者（1.4%）为III型MC。从术前评估到术后6个月和1年评估，疼痛水平VAS和ODI显著降低。不同类型的MC之间手术结果（VAS和ODI）无显著差异。

结论

后路融合术是治疗不稳定腰椎患者的有效方法。MC对这些患者的手术结果没有显著影响。