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高三尖杉酯碱：在血液系统恶性肿瘤、多种癌症和其他生物医学应用中的疗效的最新见解。

Homoharringtonine: updated insights into its efficacy in hematological malignancies, diverse cancers and other biomedical applications.

机构信息

Department of Botany, Faculty of Science, University of Allahabad, Prayagraj, Uttar Pradesh, 211002, India.

Department of Botany, Molecular and Applied Mycology and Plant Pathology Laboratory, University of Calcutta, 35, Ballygung Circular Road, Kolkata, India.

出版信息

Eur J Med Res. 2024 May 4;29(1):269. doi: 10.1186/s40001-024-01856-x.

DOI:10.1186/s40001-024-01856-x
PMID:38704602
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11069164/
Abstract

HHT has emerged as a notable compound in the realm of cancer treatment, particularly for hematological malignancies. Its multifaceted pharmacological properties extend beyond traditional applications, warranting an extensive review of its mechanisms and efficacy. This review aims to synthesize comprehensive insights into the efficacy of HHT in treating hematological malignancies, diverse cancers, and other biomedical applications. It focuses on elucidating the molecular mechanisms, therapeutic potential, and broader applications of HHT. A comprehensive search for peer-reviewed papers was conducted across various academic databases, including ScienceDirect, Web of Science, Scopus, American Chemical Society, Google Scholar, PubMed/MedLine, and Wiley. The review highlights HHT's diverse mechanisms of action, ranging from its role in leukemia treatment to its emerging applications in managing other cancers and various biomedical conditions. It underscores HHT's influence on cellular processes, its efficacy in clinical settings, and its potential to alter pathological pathways. HHT demonstrates significant promise in treating various hematological malignancies and cancers, offering a multifaceted approach to disease management. Its ability to impact various physiological pathways opens new avenues for therapeutic applications. This review provides a consolidated foundation for future research and clinical applications of HHT in diverse medical fields.

摘要

HHT 已成为癌症治疗领域的一个显著化合物，特别是在血液系统恶性肿瘤方面。其多方面的药理学特性超出了传统应用的范围，因此需要对其机制和疗效进行广泛的评估。本综述旨在综合了解 HHT 在治疗血液系统恶性肿瘤、多种癌症和其他生物医学应用方面的疗效。重点阐述了 HHT 的分子机制、治疗潜力和更广泛的应用。通过在多个学术数据库（如 ScienceDirect、Web of Science、Scopus、美国化学学会、Google Scholar、PubMed/MedLine 和 Wiley）中进行了全面的同行评审论文搜索。本综述强调了 HHT 的多种作用机制，包括其在白血病治疗中的作用以及在管理其他癌症和各种生物医学病症中的新应用。突出了 HHT 对细胞过程的影响、其在临床环境中的疗效以及改变病理途径的潜力。HHT 在治疗各种血液系统恶性肿瘤和癌症方面具有显著的应用前景，为疾病管理提供了一种多方面的方法。其影响各种生理途径的能力为治疗应用开辟了新的途径。本综述为未来在不同医学领域研究和应用 HHT 提供了一个综合的基础。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7f0/11069164/6c68122cfa15/40001_2024_1856_Fig7_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7f0/11069164/6c68122cfa15/40001_2024_1856_Fig7_HTML.jpg
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