双醋瑞因：一种用于治疗大鼠实验性牙周炎的潜在治疗药物。
Diacerein: A potential therapeutic drug for the management of experimental periodontitis in rats.
作者信息
Zaki Basma Mostafa, Mahmoud Enji Ahmed, Aly Azza Ahmed
机构信息
Surgery and Oral Medicine Department, Oral and Dental Research Division, National Research Centre, Cairo, Egypt.
Oral Medicine and Periodontology Department, Faculty of Oral and Dental Medicine, Cairo University, Cairo, Egypt.
出版信息
Electron Physician. 2015 Sep 16;7(5):1290-5. doi: 10.14661/1290. eCollection 2015 Sep.
INTRODUCTION
Knowledge about the pathogenic process in the progression of periodontal disease indicates that the central cause of periodontal disease is the loss of a healthy balance between microbial virulence factors and the host's inflammatory response. The aim of this study was to evaluate the potential effectiveness of diacerein as an anti-inflammatory drug in the management of experimental periodontitis in rats.
METHODS
The study included 60 albino rats that were divided into two groups. Periodontitis was induced in both groups. The drug group received systemic administration of diacerein, and the control group received a placebo. IL-1ß was measured two weeks after the induction of periodontitis and before the administration of the drug (baseline measurement), and it was measured again at the end of two and end of four weeks after scaling and root planning and diacerein administration.
RESULTS
The results indicated that there was a significant decrease in IL-1ß level in both groups. For the control group, there were significant decreases of the IL-1ß values from the baseline to two weeks and also from the baseline to four weeks, with p-values of 0.0001 for both comparisons. The same results were obtained for the drug group.
CONCLUSION
It was concluded that it is likely that diacerein may play a therapeutic role as a potent anti-inflammatory drug in the management of periodontitis.
引言
关于牙周病进展过程中的致病机制的知识表明，牙周病的主要病因是微生物毒力因子与宿主炎症反应之间健康平衡的丧失。本研究的目的是评估双醋瑞因作为一种抗炎药物在大鼠实验性牙周炎治疗中的潜在效果。
方法
该研究纳入60只白化大鼠，分为两组。两组均诱导牙周炎。药物组接受双醋瑞因全身给药，对照组接受安慰剂。在诱导牙周炎两周后且给药前（基线测量）测量白细胞介素-1β（IL-1β），在进行龈下刮治和根面平整以及给予双醋瑞因后两周末和四周末再次测量。
结果
结果表明两组的IL-1β水平均显著降低。对于对照组，从基线到两周以及从基线到四周，IL-1β值均显著降低，两次比较的p值均为0.0001。药物组也得到了相同的结果。
结论
得出的结论是，双醋瑞因作为一种有效的抗炎药物在牙周炎治疗中可能发挥治疗作用。
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