Padmavathy Kesavaram, Praveen Shabana, Madhavan Radha, Krithika Nagarajan, Kiruthiga Alexander
Assosciate Professor, Research Laboratory for Oral and Systemic Health, Department of Microbiology, Sree Balaji Dental College and Hospital, Bharath University , Chennai, India .
Lecturer, Department of Microbiology, SRM Medical College Hospital and Research Centre, SRM University , Kattankulathur, Chennai, India .
J Clin Diagn Res. 2015 Aug;9(8):DD05-6. doi: 10.7860/JCDR/2015/13856.6378. Epub 2015 Aug 1.
Prolonged hospitalization and exposure to third generation cephalosporins are reported to facilitate the acquisition and colonization of Vancomycin Resistant Enterococci (VRE). Though VRE is not uncommon in India, urinary tract infection with a vanA genotype is a cause of serious concern as VRE co-exhibit resistance to aminoglycosides. In India, majority of the VRE isolates recovered from hospitalized patients include Enterococcus faecium. We report a case of catheter associated urinary tract infection by an endogenous, multidrug resistant E. faecalis of vanA genotype following prolonged hospitalization, ICU stay, catheterisation and exposure to 3G cephalosporin and metronidazole. The patient responded to linezolid therapy.
据报道，长期住院以及接触第三代头孢菌素会促使耐万古霉素肠球菌（VRE）的获得与定植。尽管VRE在印度并不罕见，但vanA基因型的尿路感染是一个严重问题，因为VRE对氨基糖苷类药物也具有耐药性。在印度，从住院患者中分离出的VRE大多数为粪肠球菌。我们报告了一例在长期住院、入住重症监护病房、留置导尿管以及接触第三代头孢菌素和甲硝唑后，由内源性、耐多药的vanA基因型粪肠球菌引起的导管相关性尿路感染病例。该患者对利奈唑胺治疗有反应。
