粪肠球菌引起的导管相关尿路感染的临床微生物学调查：vanA基因型
Clinico-Microbiological Investigation of Catheter Associated Urinary Tract Infection by Enterococcus faecalis: vanA Genotype.
作者信息
Padmavathy Kesavaram, Praveen Shabana, Madhavan Radha, Krithika Nagarajan, Kiruthiga Alexander
机构信息
Assosciate Professor, Research Laboratory for Oral and Systemic Health, Department of Microbiology, Sree Balaji Dental College and Hospital, Bharath University , Chennai, India .
Lecturer, Department of Microbiology, SRM Medical College Hospital and Research Centre, SRM University , Kattankulathur, Chennai, India .
出版信息
J Clin Diagn Res. 2015 Aug;9(8):DD05-6. doi: 10.7860/JCDR/2015/13856.6378. Epub 2015 Aug 1.
Abstract
Prolonged hospitalization and exposure to third generation cephalosporins are reported to facilitate the acquisition and colonization of Vancomycin Resistant Enterococci (VRE). Though VRE is not uncommon in India, urinary tract infection with a vanA genotype is a cause of serious concern as VRE co-exhibit resistance to aminoglycosides. In India, majority of the VRE isolates recovered from hospitalized patients include Enterococcus faecium. We report a case of catheter associated urinary tract infection by an endogenous, multidrug resistant E. faecalis of vanA genotype following prolonged hospitalization, ICU stay, catheterisation and exposure to 3G cephalosporin and metronidazole. The patient responded to linezolid therapy.
摘要
据报道，长期住院以及接触第三代头孢菌素会促使耐万古霉素肠球菌（VRE）的获得与定植。尽管VRE在印度并不罕见，但vanA基因型的尿路感染是一个严重问题，因为VRE对氨基糖苷类药物也具有耐药性。在印度，从住院患者中分离出的VRE大多数为粪肠球菌。我们报告了一例在长期住院、入住重症监护病房、留置导尿管以及接触第三代头孢菌素和甲硝唑后，由内源性、耐多药的vanA基因型粪肠球菌引起的导管相关性尿路感染病例。该患者对利奈唑胺治疗有反应。
相似文献
1
Clinico-Microbiological Investigation of Catheter Associated Urinary Tract Infection by Enterococcus faecalis: vanA Genotype.粪肠球菌引起的导管相关尿路感染的临床微生物学调查：vanA基因型
J Clin Diagn Res. 2015 Aug;9(8):DD05-6. doi: 10.7860/JCDR/2015/13856.6378. Epub 2015 Aug 1.
2
Antibiotic activity against urinary tract infection (UTI) isolates of vancomycin-resistant enterococci (VRE): results from the 2002 North American Vancomycin Resistant Enterococci Susceptibility Study (NAVRESS).针对耐万古霉素肠球菌（VRE）引起的尿路感染（UTI）分离株的抗生素活性：2002年北美耐万古霉素肠球菌药敏试验（NAVRESS）的结果。
J Antimicrob Chemother. 2003 Sep;52(3):382-8. doi: 10.1093/jac/dkg352. Epub 2003 Jul 29.
3
High incidence of virulence determinants, aminoglycoside and vancomycin resistance in enterococci isolated from hospitalized patients in Northwest Iran.伊朗西北部住院患者分离肠球菌的毒力决定因素、氨基糖苷类和万古霉素耐药率较高。
BMC Infect Dis. 2019 Aug 27;19(1):744. doi: 10.1186/s12879-019-4395-3.
4
Gastrointestinal Colonization with Vancomycin-Resistant Enterococci In Hospitalized and Outpatients.住院患者和门诊患者中耐万古霉素肠球菌的胃肠道定植
Open Access Maced J Med Sci. 2015 Mar 15;3(1):7-11. doi: 10.3889/oamjms.2015.002. Epub 2014 Nov 5.
5
Prevalence and determinants of fecal colonization with vancomycin-resistant Enterococcus in hospitalized patients in The Netherlands.荷兰住院患者中耐万古霉素肠球菌粪便定植的患病率及影响因素
Infect Control Hosp Epidemiol. 2000 Aug;21(8):520-4. doi: 10.1086/501797.
6
Vancomycin-resistant enterococci.耐万古霉素肠球菌
Ann Pharmacother. 1996 Jun;30(6):615-24. doi: 10.1177/106002809603000610.
7
Emergence of vanA gene among vancomycin-resistant enterococci in a tertiary care hospital of North - East India.印度东北部一家三级护理医院中耐万古霉素肠球菌vanA基因的出现。
Indian J Med Res. 2016 Mar;143(3):357-61. doi: 10.4103/0971-5916.182627.
8
Species, antibiotic susceptibility profiles and van gene frequencies among enterococci isolated from patients at Mulago National Referral Hospital in Kampala, Uganda.乌干达坎帕拉市穆拉戈国家转诊医院患者肠球菌的种属、抗生素药敏谱和耐万古霉素基因频率。
BMC Infect Dis. 2019 May 31;19(1):486. doi: 10.1186/s12879-019-4136-7.
9
Characterization of clinical enterococci isolates, focusing on the vancomycin-resistant enterococci in a tertiary hospital in China: based on the data from 2013 to 2018.中国某三甲医院 2013 年至 2018 年临床肠球菌的耐药特征分析，重点关注耐万古霉素肠球菌。
BMC Infect Dis. 2020 May 19;20(1):356. doi: 10.1186/s12879-020-05078-4.
10
Genotypic characterization of a nosocomial outbreak of VanA Enterococcus faecalis.粪肠球菌VanA医院感染暴发的基因分型特征
Microb Drug Resist. 1996 Summer;2(2):231-7. doi: 10.1089/mdr.1996.2.231.
引用本文的文献
1
The promising anti-virulence activity of candesartan, domperidone, and miconazole on Staphylococcus aureus.坎地沙坦、多潘立酮和咪康唑对金黄色葡萄球菌具有潜在的抗毒活性。
Braz J Microbiol. 2022 Mar;53(1):1-18. doi: 10.1007/s42770-021-00655-4. Epub 2021 Nov 13.
2
Corrigendum: Cinnamaldehyde Inhibits Virulence Factors and Protects against Infection in a Model.勘误：肉桂醛抑制毒力因子并在模型中预防感染。
Front Microbiol. 2021 Jan 15;11:628074. doi: 10.3389/fmicb.2020.628074. eCollection 2020.
3
Eco friendly silver nanoparticles synthesis by Brassica oleracea and its antibacterial, anticancer and antioxidant properties.十字花科芸薹属植物合成环保型银纳米粒子及其抗菌、抗癌和抗氧化特性。
Sci Rep. 2020 Oct 29;10(1):18564. doi: 10.1038/s41598-020-74371-8.
4
Comparative study of antimicrobial resistance and biofilm formation among Gram-positive uropathogens isolated from community-acquired urinary tract infections and catheter-associated urinary tract infections.从社区获得性尿路感染和导管相关性尿路感染中分离出的革兰氏阳性尿路病原体的耐药性和生物膜形成的比较研究。
Infect Drug Resist. 2019 Apr 23;12:957-963. doi: 10.2147/IDR.S200988. eCollection 2019.
5
High frequency of vancomycin resistant in children: an alarming concern.儿童中耐万古霉素的高频率：一个令人担忧的问题。
J Prev Med Hyg. 2016 Dec;57(4):E201-E204.
6
Cinnamaldehyde Inhibits Virulence Factors and Protects against Infection in a Model.肉桂醛在模型中抑制毒力因子并预防感染。
Front Microbiol. 2016 Dec 21;7:2052. doi: 10.3389/fmicb.2016.02052. eCollection 2016.
7
Identification of Genes Coding Aminoglycoside Modifying Enzymes in E. coli of UTI Patients in India.印度尿路感染患者大肠杆菌中编码氨基糖苷修饰酶的基因鉴定
ScientificWorldJournal. 2016;2016:1875865. doi: 10.1155/2016/1875865. Epub 2016 Jun 15.
本文引用的文献
1
Clinical, epidemiological, and microbiological profile of patients with vancomycin-resistant enterococci from a tertiary care hospital.来自一家三级护理医院的耐万古霉素肠球菌患者的临床、流行病学和微生物学特征
J Glob Infect Dis. 2012 Apr;4(2):137-8. doi: 10.4103/0974-777X.96784.
2
Vancomycin resistant Enterococci in a tertiary care hospital in Mumbai.孟买一家三级护理医院中的耐万古霉素肠球菌
Indian J Med Microbiol. 2009 Oct-Dec;27(4):375-6. doi: 10.4103/0255-0857.55451.
3
Biofilm formation by enterococci.肠球菌生物膜的形成
J Med Microbiol. 2007 Dec;56(Pt 12):1581-1588. doi: 10.1099/jmm.0.47331-0.
4
Vancomycin-resistant enterococci: colonization, infection, detection, and treatment.耐万古霉素肠球菌：定植、感染、检测与治疗
Mayo Clin Proc. 2006 Apr;81(4):529-36. doi: 10.4065/81.4.529.
5
Enterococcal surface protein, Esp, enhances biofilm formation by Enterococcus faecalis.肠球菌表面蛋白Esp增强粪肠球菌的生物膜形成。
Infect Immun. 2004 Oct;72(10):6032-9. doi: 10.1128/IAI.72.10.6032-6039.2004.
6
Nosocomial infection with vancomycin-dependent enterococci.耐万古霉素肠球菌的医院感染
Emerg Infect Dis. 2004 Jul;10(7):1277-81. doi: 10.3201/eid1007.030993.
7
Enterococcal infections with special reference to phenotypic characterization & drug resistance.肠球菌感染，特别涉及表型特征及耐药性
Indian J Med Res. 2004 May;119 Suppl:22-5.
8
Significance of vancomycin resistant enterococci from urinary specimens at a tertiary care centre in northern India.印度北部一家三级医疗中心尿液标本中耐万古霉素肠球菌的意义
Indian J Med Res. 2004 Feb;119(2):72-4.
9
Esp-independent biofilm formation by Enterococcus faecalis.粪肠球菌不依赖于表面蛋白的生物膜形成
J Bacteriol. 2004 Jan;186(1):154-63. doi: 10.1128/JB.186.1.154-163.2004.
10
Multiplex PCR for detection of aminoglycoside resistance genes in enterococci.用于检测肠球菌中氨基糖苷类耐药基因的多重聚合酶链反应
Antimicrob Agents Chemother. 2003 Apr;47(4):1423-6. doi: 10.1128/AAC.47.4.1423-1426.2003.
Zotero 插件