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原发性干燥综合征中产生白介素-17 的 CD4+CD161+ 细胞及其亚群的临床相关性。

The Clinical Relevance of IL-17-Producing CD4+CD161+ Cell and Its Subpopulations in Primary Sjögren's Syndrome.

机构信息

Department of Rheumatology & Immunology, Clinical Immunology Center, Peking University People's Hospital, 11 Xizhimen South Street, Beijing 100044, China.

出版信息

J Immunol Res. 2015;2015:307453. doi: 10.1155/2015/307453. Epub 2015 Sep 8.

DOI:10.1155/2015/307453
PMID:26436101
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4578753/
Abstract

OBJECTIVE

Th17 cells have been demonstrated to play an important role in the onset and development of primary Sjögren's syndrome (pSS). In this study, we evaluated the expansion and clinical significance of circulating CD4+CD161+ T cell and its "effector" (CD4+CD25-CD161+ T cell) and "regulatory" (CD4+CD25+CD161+ T cell) subpopulations.

METHODS

Fifty-eight pSS patients and 16 healthy controls (HCs) were recruited in our study. The cell populations and intracellular IL-17 expression were analyzed by flow cytometry. The disease activity was evaluated by the EULAR-SS Disease Activity Index (ESSDAI). Autoantibodies were measured by ELISA or indirect immunofluorescence assay.

RESULTS

The CD161+ T cell fractions showed higher proportions of IL-17-producing cells. The frequencies of the overall CD4+CD161+ T cell population and its effector subset were positively correlated with disease activity parameters and more severe disease manifestations. A significant elevation of the CD4+CD25+CD161+ T cell subpopulation was observed in the peripheral blood of pSS patients compared to HCs and this subset showed decreased regulatory functions compared with the CD4+CD25+CD161- population.

CONCLUSION

Circulating CD4+CD161+ T cell populations associated with pSS disease activity and severity. These cells might be involved in the development of pSS and could be potential therapeutic targets in the treatment of pSS.

摘要

目的

Th17 细胞已被证明在原发性干燥综合征（pSS）的发病和发展中起重要作用。在本研究中，我们评估了循环 CD4+CD161+T 细胞及其“效应子”（CD4+CD25-CD161+T 细胞）和“调节子”（CD4+CD25+CD161+T 细胞）亚群的扩增及其临床意义。

方法

我们招募了 58 例 pSS 患者和 16 名健康对照者（HCs）。通过流式细胞术分析细胞群和细胞内 IL-17 的表达。采用 EULAR-SS 疾病活动指数（ESSDAI）评估疾病活动度。通过 ELISA 或间接免疫荧光法测量自身抗体。

结果

CD161+T 细胞亚群表现出更高比例的产生 IL-17 的细胞。总 CD4+CD161+T 细胞群体及其效应子亚群的频率与疾病活动参数和更严重的疾病表现呈正相关。与 HCs 相比，pSS 患者外周血中观察到 CD4+CD25+CD161+T 细胞亚群显著升高，与 CD4+CD25+CD161-群体相比，该亚群的调节功能降低。

结论

循环 CD4+CD161+T 细胞群体与 pSS 疾病活动和严重程度相关。这些细胞可能参与了 pSS 的发生，可能成为治疗 pSS 的潜在治疗靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0751/4578753/94bd7b4dbe96/JIR2015-307453.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0751/4578753/0d5f2c458122/JIR2015-307453.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0751/4578753/445b025bdc9c/JIR2015-307453.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0751/4578753/4c0bba12ecc2/JIR2015-307453.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0751/4578753/446a56adc39d/JIR2015-307453.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0751/4578753/0f588fd9ecb8/JIR2015-307453.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0751/4578753/d077cf9c5131/JIR2015-307453.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0751/4578753/94bd7b4dbe96/JIR2015-307453.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0751/4578753/0d5f2c458122/JIR2015-307453.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0751/4578753/445b025bdc9c/JIR2015-307453.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0751/4578753/4c0bba12ecc2/JIR2015-307453.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0751/4578753/446a56adc39d/JIR2015-307453.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0751/4578753/0f588fd9ecb8/JIR2015-307453.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0751/4578753/d077cf9c5131/JIR2015-307453.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0751/4578753/94bd7b4dbe96/JIR2015-307453.007.jpg

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