Higashida-Konishi Misako, Izumi Keisuke, Shimada Tatsuya, Hama Satoshi, Oshige Tatsuhiro, Oshima Hisaji, Okano Yutaka
Division of Rheumatology, Department of Medicine, National Hospital Organization Tokyo Medical Center, 1528902, Higashigaoka 2-5-1, Meguro-ku, Tokyo, Japan.
Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, 1608582, Shinanomachi 35, Shinjyuku-ku, Tokyo, Japan.
World Allergy Organ J. 2023 Jan 27;16(2):100745. doi: 10.1016/j.waojou.2023.100745. eCollection 2023 Feb.
This study aimed to evaluate the prevalence of allergic disorders in patients with primary Sjögren's syndrome (pSS), compare it with that of patients with rheumatoid arthritis (RA), and examine the risk factors in patients with pSS.
We retrospectively examined the records of patients diagnosed with pSS and RA who regularly visited our department between 2010 and 2020. Allergic disorders included drug allergy, food allergy, allergic contact dermatitis (ACD), allergic rhinitis (AR)/allergic conjunctivitis (AC), and asthma.
Patients with pSS (292 patients) had a higher prevalence of food allergy, drug allergy, and AR/AC than those with RA (413 patients). The multivariate analysis revealed that patients with pSS who had drug allergy had a higher prevalence of food allergy, higher eosinophil levels, and higher positivity rates of anti-SS-related antigen A (SSA) antibodies than those without drug allergy; those with food allergy had a higher rate of ACD than those without food allergy and vice versa; those with AR/AC had a higher rate of ACD and asthma and higher eosinophil levels than those without AR/AC; those with asthma had a higher rate of AR/AC than those without asthma.
Patients with pSS had a higher prevalence of allergic disorders than those with RA. Among patients with pSS, the risk factors for drug allergy were food allergy, higher eosinophil levels, and positivity for anti-SSA antibodies, the risk factor for food allergy was ACD and vice versa, the risk factors for AR/AC were ACD, asthma, and high eosinophil levels, and the risk factor for asthma was AR/AC.
本研究旨在评估原发性干燥综合征（pSS）患者中过敏性疾病的患病率，将其与类风湿关节炎（RA）患者的患病率进行比较，并研究pSS患者的危险因素。
我们回顾性研究了2010年至2020年间定期到我院就诊的诊断为pSS和RA的患者记录。过敏性疾病包括药物过敏、食物过敏、过敏性接触性皮炎（ACD）、过敏性鼻炎（AR）/过敏性结膜炎（AC）和哮喘。
pSS患者（292例）食物过敏、药物过敏和AR/AC的患病率高于RA患者（413例）。多因素分析显示，有药物过敏的pSS患者食物过敏患病率更高、嗜酸性粒细胞水平更高、抗SS相关抗原A（SSA）抗体阳性率高于无药物过敏者；有食物过敏者ACD发生率高于无食物过敏者，反之亦然；有AR/AC者ACD和哮喘发生率更高、嗜酸性粒细胞水平高于无AR/AC者；有哮喘者AR/AC发生率高于无哮喘者。
pSS患者过敏性疾病的患病率高于RA患者。在pSS患者中，药物过敏的危险因素是食物过敏、较高的嗜酸性粒细胞水平和抗SSA抗体阳性；食物过敏的危险因素是ACD，反之亦然；AR/AC的危险因素是ACD、哮喘和高嗜酸性粒细胞水平；哮喘的危险因素是AR/AC。
