Gonzalez Luisa, Alvarez Jose, Weinstein Erica, Korenis Panagiota
Bronx Lebanon Hospital Center, Albert Einstein College of Medicine Bronx, New York ; Albert Einstein College of Medicine Bronx, New York.
Bronx Lebanon Hospital Center, Albert Einstein College of Medicine Bronx, New York.
Mol Genet Genomic Med. 2015 Sep;3(5):391-5. doi: 10.1002/mgg3.114. Epub 2014 Dec 3.
Schizophrenia is associated with high mortality and morbidity. The etiology of schizophrenia remains unclear, studies implicate a multifactorial origin with genetic and environmental factors. The adenomatous polyposis coli (APC) gene has been associated with FAP (familial adenomatous polyposis), and studies have linked it to schizophrenia. However, there are few studies which examine the association between FAP and schizophrenia. Limited data exist regarding recommendations for genetic counseling of adolescents with comorbid psychiatric illness. A case of an adolescent with FAP who developed psychotic symptoms is presented. This case hopes to add to the literature about mental illness in those with FAP. A review of literature about the role of APC in schizophrenia as well as implications of genetic counseling on those who suffer with mental illness will be discussed.
精神分裂症与高死亡率和高发病率相关。精神分裂症的病因仍不清楚，研究表明其起源是多因素的，涉及遗传和环境因素。腺瘤性息肉病 coli（APC）基因与家族性腺瘤性息肉病（FAP）有关，并且研究已将其与精神分裂症联系起来。然而，很少有研究探讨 FAP 与精神分裂症之间的关联。关于合并精神疾病的青少年遗传咨询建议的数据有限。本文介绍了一例患有 FAP 并出现精神病症状的青少年病例。该病例希望能为有关 FAP 患者精神疾病的文献增添内容。将讨论关于 APC 在精神分裂症中的作用以及遗传咨询对精神疾病患者影响的文献综述。
