慢性肝病中的NADPH氧化酶
NADPH Oxidases in Chronic Liver Diseases.
作者信息
Jiang Joy X, Török Natalie J
机构信息
Department of Internal Medicine, Division of Gastroenterology and Hepatology, UC Davis Medical Center, 4150 V Street, Sacramento, CA 95817, USA.
出版信息
Adv Hepatol. 2014 Nov 30;2014. doi: 10.1155/2014/742931.
Abstract
Oxidative stress is a common feature observed in a wide spectrum of chronic liver diseases including viral hepatitis, alcoholic, and nonalcoholic steatohepatitis. The nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (NOXs) are emerging as major sources of reactive oxygen species (ROS). Several major isoforms are expressed in the liver, including NOX1, NOX2, and NOX4. While the phagocytic NOX2 has been known to play an important role in Kupffer cell and neutrophil phagocytic activity and inflammation, the nonphagocytic NOX homologues are increasingly recognized as key enzymes in oxidative injury and wound healing. In this review, we will summarize the current advances in knowledge on the regulatory pathways of NOX activation, their cellular distribution, and their role in the modulation of redox signaling in liver diseases.
摘要
氧化应激是在包括病毒性肝炎、酒精性和非酒精性脂肪性肝炎在内的多种慢性肝病中观察到的一个共同特征。烟酰胺腺嘌呤二核苷酸磷酸（NADPH）氧化酶（NOXs）正成为活性氧（ROS）的主要来源。肝脏中表达几种主要的异构体，包括NOX1、NOX2和NOX4。虽然已知吞噬性NOX2在库普弗细胞和中性粒细胞的吞噬活性及炎症中起重要作用，但非吞噬性NOX同源物越来越被认为是氧化损伤和伤口愈合中的关键酶。在本综述中，我们将总结目前关于NOX激活调节途径、其细胞分布及其在肝病中氧化还原信号调节作用的知识进展。
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