Clinical studies of high-potency fluoride dentifrices: a review.

A review of clinical studies indicates that increasing the fluoride content above 1,000 ppm in dentifrices containing sodium monofluorophosphate increases the mean caries reduction by approximately 12%. The results of studies testing high-potency mixed-fluoride dentifrices containing both sodium fluoride and sodium monofluorophosphate are less conclusive.