基质金属蛋白酶基因多态性与类风湿关节炎易感性的关联研究：一项荟萃分析

Association Study of Matrix Metalloproteinases Gene Polymorphisms with Susceptibility to Rheumatoid Arthritis: A Meta-Analysis.

作者信息

Li Peng, Tao Sha-Sha, Zhao Meng-Qin, Li Jun, Wang Xiu, Pan Hai-Feng, Ye Dong-Qing

机构信息

a Department of Epidemiology and Biostatistics , School of Public Health, Anhui Medical University , Hefei , Anhui , PR China and.

b Anhui Provincial Laboratory of Population Health & Major Disease Screening and Diagnosis, Anhui Medical University , Hefei , Anhui , PR China.

出版信息

Immunol Invest. 2015;44(7):603-15. doi: 10.3109/08820139.2015.1056346.

DOI:10.3109/08820139.2015.1056346

PMID:26436849

Abstract

OBJECTIVE

Association of matrix metalloproteinases (MMPs) gene polymorphisms with rheumatoid arthritis is controversial. We conduct a meta-analysis to clarify this dispute.

METHODS

We systematically searched the electronic PUBMED, EMBASE and CNKI databases for research articles about MMPs (MMP-1, MMP-2, MMP-3, MMP-9) gene polymorphisms and rheumatoid arthritis (RA) up to January 2015. According to the heterogeneity, fixed-effects or random-effects models were used to calculate crude odds ratios (ORs) and 95% confidence intervals (95% CIs).

RESULTS

A total of 11 articles involving 2143 cases and 2049 controls were included in this meta-analysis. Overall, no significant associations were observed between MMP-1-1607 1G/2G polymorphism and RA. Stratification by ethnicity, no significant associations were observed in Caucasian populations. Similarly, no significant associations were observed between MMP-3-1171 5A/6A, MMP-9-1562 C/T polymorphisms and RA in overall and Caucasian populations, respectively. However, a weak association was found between MMP-2-1306 C/T polymorphism and RA (C vs. T, OR = 0.813, 95%CI = 0.694-0.953, p = 0.010) in overall populations.

CONCLUSIONS

The present meta-analysis suggests that MMP-1-1607 1G/2G, MMP-3-1171 5A/6A, MMP-9-1562 C/T polymorphisms are not associated with the susceptibility of RA, but MMP-2 -1306 C/T is weakly associated with susceptibility to RA. Further studies with more sample size are needed for definitive conclusions.

摘要

目的

基质金属蛋白酶（MMPs）基因多态性与类风湿关节炎的关联存在争议。我们进行一项荟萃分析以阐明这一争议。

方法

我们系统检索了电子数据库PUBMED、EMBASE和CNKI，以查找截至2015年1月有关MMPs（MMP - 1、MMP - 2、MMP - 3、MMP - 9）基因多态性与类风湿关节炎（RA）的研究文章。根据异质性，采用固定效应或随机效应模型计算粗比值比（ORs）和95%置信区间（95% CIs）。

结果

本荟萃分析共纳入11篇文章，涉及2143例病例和2049例对照。总体而言，未观察到MMP - 1 - 1607 1G/2G多态性与RA之间存在显著关联。按种族分层，在白种人群中未观察到显著关联。同样，分别在总体人群和白种人群中，未观察到MMP - 3 - 1171 5A/6A、MMP - 9 - 1562 C/T多态性与RA之间存在显著关联。然而，在总体人群中发现MMP - 2 - 1306 C/T多态性与RA之间存在弱关联（C vs. T，OR = 0.813，95%CI = 0.694 - 0.953，p = 0.010）。