Weng Hong, Yan Yan, Jin Ying-Hui, Meng Xiang-Yu, Mo Yuan-Yuan, Zeng Xian-Tao
Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan 430071, P. R. China.
Department of Stomatology, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, P. R. China.
Sci Rep. 2016 Apr 20;6:24812. doi: 10.1038/srep24812.
We aimed to systematically investigate the potential association of matrix metalloproteinase (MMP)-9, -3, -2, and -8 gene polymorphisms with susceptibility to periodontitis using meta-analysis. A literature search in PubMed, Embase, and Web of Science was conducted to obtain relevant publications. Finally a total of 16 articles with 24 case-control studies (nine on MMP-9-1562 C/T, seven on MMP-3-1171 A5/A6, four on MMP-2-753C/T, and four on MMP-8-799 C/T) were considered in this meta-analysis. The results based on 2,724 periodontitis patients and 3,438 controls showed that MMP-9-1562C/T, MMP-3-1171 A5/A6, and MMP-8-799C/T polymorphisms were associated with periodontitis susceptibility. No significant association was found between MMP-2-753 C/T and periodontitis susceptibility. Subgroup analyses suggested that the MMP-9-1562 C/T polymorphism reduced chronic periodontitis susceptibility and MMP-3-1171 A5/A6 polymorphism increased chronic periodontitis susceptibility. In summary, current evidence demonstrated that MMP-9-753 C/T polymorphism reduced the risk of periodontitis, MMP-3-1171 5A/6A and MMP-8-799 C/T polymorphisms increased the risk of periodontitis, and MMP-2-753 C/T was not associated with risk of periodontitis.
我们旨在通过荟萃分析系统地研究基质金属蛋白酶（MMP）-9、-3、-2和-8基因多态性与牙周炎易感性之间的潜在关联。在PubMed、Embase和Web of Science中进行文献检索以获取相关出版物。最终，本荟萃分析纳入了16篇文章中的24项病例对照研究（9项关于MMP-9 -1562 C/T，7项关于MMP-3 -1171 A5/A6，4项关于MMP-2 -753C/T，4项关于MMP-8 -799 C/T）。基于2724例牙周炎患者和3438例对照的结果表明，MMP-9 -1562C/T、MMP-3 -1171 A5/A6和MMP-8 -799C/T多态性与牙周炎易感性相关。未发现MMP-2 -753 C/T与牙周炎易感性之间存在显著关联。亚组分析表明，MMP-9 -1562 C/T多态性降低了慢性牙周炎易感性，而MMP-3 -1171 A5/A6多态性增加了慢性牙周炎易感性。总之，目前的证据表明，MMP-9 -753 C/T多态性降低了牙周炎风险，MMP-3 -1171 5A/6A和MMP-8 -799 C/T多态性增加了牙周炎风险，而MMP-2 -753 C/T与牙周炎风险无关。
