Agosto Luis M, Gagne Matthew, Henderson Andrew J
Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA.
Graduate Program in Microbiology, Boston University School of Medicine, Boston, MA 02118, USA.
Genes (Basel). 2015 Sep 30;6(4):957-76. doi: 10.3390/genes6040957.
Chromatin influences Human Immunodeficiency Virus (HIV) integration and replication. This review highlights critical host factors that influence chromatin structure and organization and that also impact HIV integration, transcriptional regulation and latency. Furthermore, recent attempts to target chromatin associated factors to reduce the HIV proviral load are discussed.
染色质影响人类免疫缺陷病毒（HIV）的整合与复制。本综述重点介绍了影响染色质结构和组织，同时也影响HIV整合、转录调控和潜伏的关键宿主因子。此外，还讨论了近期针对与染色质相关因子以降低HIV前病毒载量的尝试。
