Ibarra Arkaitz, Hetzer Martin W
Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037, USA.
Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037, USA
Genes Dev. 2015 Feb 15;29(4):337-49. doi: 10.1101/gad.256495.114.
Nuclear pore complexes (NPCs) are composed of several copies of ∼30 different proteins called nucleoporins (Nups). NPCs penetrate the nuclear envelope (NE) and regulate the nucleocytoplasmic trafficking of macromolecules. Beyond this vital role, NPC components influence genome functions in a transport-independent manner. Nups play an evolutionarily conserved role in gene expression regulation that, in metazoans, extends into the nuclear interior. Additionally, in proliferative cells, Nups play a crucial role in genome integrity maintenance and mitotic progression. Here we discuss genome-related functions of Nups and their impact on essential DNA metabolism processes such as transcription, chromosome duplication, and segregation.
核孔复合体（NPCs）由大约30种不同的蛋白质组成，这些蛋白质被称为核孔蛋白（Nups），有多个拷贝。核孔复合体穿透核膜（NE），并调节大分子的核质运输。除了这一重要作用外，核孔复合体的组成成分还以一种不依赖运输的方式影响基因组功能。核孔蛋白在基因表达调控中发挥着进化上保守的作用，在后生动物中，这种作用延伸到细胞核内部。此外，在增殖细胞中，核孔蛋白在维持基因组完整性和有丝分裂进程中发挥着关键作用。在这里，我们讨论核孔蛋白与基因组相关的功能，以及它们对转录、染色体复制和分离等基本DNA代谢过程的影响。
