Sodsanrat Kanchid, Saeaib Nungrutai, Liabsuetrakul Tippawan
J Med Assoc Thai. 2015 Aug;98(8):725-33.
To study the clinical manifestations and survival outcomes of neuroendocrine tumor of the uterine cervix (NTUC) and compare them with those of squamous cell carcinoma (SCCA) MATERIAL AND METHOD: A case-control study was conducted. In the study group, we included patients whose tumors were described in the original pathology reports as NTUC. For the control group, we calculated the sample size based on a formula according to survival rate. The ratio of cases to controls was 1:4. Patients with a diagnosis of SCCA of the uterine cervix and treated between January 2003 and December 2011 in Son gklanagarind Hospital were included in the control group according to stage and year of NT UC diagnos is. The patients 'characteristics, method of treatment, treatment outcomes, and survival of the two groups were compared. The prognostic factors among patients with NTUC were analyzed using the Cox regression.
Of the 2,835 cervical carcinoma cases studied, 44 (1.6%) were NTUC. NTUC patients had a lower mean age at diagnosis, received more multimodality treatments, had a lower complete response rate, a higher recurrence rate, and more distant metastasis than their SCCA counterparts. A significantly lower 2-year and 5-year survival was detected in NTUC compared with SCCA (62% and 52% vs. 97% and 85%, respectively, p < 0.01). In the univariate analysis, the number of sexual partners, stage of disease, surgery treatment, status of response, and site of recurrence predicted a poorer overall survival in NTUC. However, these factors were not found to be statistically significant prognostic factors on multivariate analysis.
A poorer treatment outcome and prognosis were found in NTUC compared with SCCA. Moreover a poorer prognosis was observed in NTUC patients with an advanced-stage disease, non-surgery treatment, progressive disease, and distant metastasis recurrence than in those with SCCA patients. Multimodality treatments should be considered in NTUC to improve survival. Additionally close monitoring may be necessary in this group of patients.
研究子宫颈神经内分泌肿瘤（NTUC）的临床表现和生存结局，并与鳞状细胞癌（SCCA）进行比较。
进行了一项病例对照研究。研究组纳入原始病理报告中描述为NTUC的患者。对照组根据生存率公式计算样本量。病例与对照的比例为1:4。根据NTUC诊断的分期和年份，将2003年1月至2011年12月在宋卡那加拉医院接受治疗的子宫颈SCCA患者纳入对照组。比较两组患者的特征、治疗方法、治疗结局和生存情况。使用Cox回归分析NTUC患者的预后因素。
在研究的2835例宫颈癌病例中，44例（1.6%）为NTUC。与SCCA患者相比，NTUC患者诊断时的平均年龄较低，接受更多的多模式治疗，完全缓解率较低，复发率较高，远处转移更多。与SCCA相比，NTUC患者的2年和5年生存率显著较低（分别为62%和52%，而SCCA为97%和85%，p<0.01）。单因素分析中，性伴侣数量、疾病分期、手术治疗、缓解状态和复发部位预示NTUC患者的总生存较差。然而，多因素分析中这些因素未被发现是具有统计学意义的预后因素。
与SCCA相比，NTUC的治疗结局和预后较差。此外，与SCCA患者相比，晚期疾病、非手术治疗、疾病进展和远处转移复发的NTUC患者预后更差。NTUC应考虑多模式治疗以提高生存率。此外，对该组患者可能需要密切监测。
