Fadıloğlu Erdem, Karalök Alper, Türkmen Osman, Asiltürk Şeyma, Öçalan Reyhan, Boran Nurettin, Ökten Heyecan, Turan Taner, Tulunay Gökhan
Etlik Zübeyde Hanım Women's Health Training and Research Hospital, Clinic of Gynecologic Oncology, Ankara, Turkey.
Etlik Zübeyde Hanım Women's Health Training and Research Hospital, Clinic of Pathology, Ankara, Turkey.
Turk J Obstet Gynecol. 2016 Jun;13(2):99-102. doi: 10.4274/tjod.72325. Epub 2016 Jun 15.
Adenoneuroendocrine carcinoma is a very rare form of cervical carcinoma that includes both endocrine and exocrine components. In general terms, these carcinomas progress aggressively and show early metastases due to the neuroendocrine component. The most important criteria related to prognosis is the stage of the disease. Without clearly determined therapeutic protocols this carcinoma is generally seen at earlier ages and causes high mortality. Many radiotherapy and multidrug chemotherapy protocols are used after surgical intervention. Detection of the neuroendocrine component of cervical tumors is achieved through immunohistochemical staining. Herein, we present a woman aged 50 years who was admitted to the hospital with abdominal pain and postmenopausal vaginal bleeding whose examination revealed a cervical tumor. A pathologic examination after surgery resulted as "adenocarcinoma and large cell neuroendocrine carcinoma." Afterwards, a combined chemotherapy regimen (cisplatin + etoposid) was administered to the patient and 6 months of progress is evaluated in this report.
腺神经内分泌癌是一种非常罕见的宫颈癌形式，它同时包含内分泌和外分泌成分。一般来说，这些癌进展迅速，由于神经内分泌成分而早期发生转移。与预后相关的最重要标准是疾病分期。由于没有明确确定的治疗方案，这种癌通常在较年轻的年龄出现，并导致高死亡率。手术干预后会使用多种放疗和多药化疗方案。宫颈肿瘤神经内分泌成分的检测通过免疫组织化学染色来实现。在此，我们报告一名50岁女性，因腹痛和绝经后阴道出血入院，检查发现宫颈肿瘤。手术后病理检查结果为“腺癌和大细胞神经内分泌癌”。随后，对该患者实施了联合化疗方案（顺铂+依托泊苷），本报告评估了6个月的病情进展情况。
