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A functional polymorphism in the CEBPE gene promoter influences acute lymphoblastic leukemia risk through interaction with the hematopoietic transcription factor Ikaros.

作者信息

Wiemels J L, de Smith A J, Xiao J, Lee S-T, Muench M O, Fomin M E, Zhou M, Hansen H M, Termuhlen A, Metayer C, Walsh K M

机构信息

Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA.

Division of Neuroepidemiology, Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA.

出版信息

Leukemia. 2016 May;30(5):1194-7. doi: 10.1038/leu.2015.251. Epub 2015 Sep 16.

DOI:10.1038/leu.2015.251
PMID:26437776
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4794412/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ff9/4794412/928d54fb601f/nihms-717029-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ff9/4794412/39147d3f0f97/nihms-717029-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ff9/4794412/928d54fb601f/nihms-717029-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ff9/4794412/39147d3f0f97/nihms-717029-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ff9/4794412/928d54fb601f/nihms-717029-f0002.jpg

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本文引用的文献

1
Stage-specific control of early B cell development by the transcription factor Ikaros.转录因子 Ikaros 对早期 B 细胞发育的阶段特异性控制。
Nat Immunol. 2014 Mar;15(3):283-93. doi: 10.1038/ni.2828. Epub 2014 Feb 9.
2
PTPRG inhibition by DNA methylation and cooperation with RAS gene activation in childhood acute lymphoblastic leukemia.DNA 甲基化抑制 PTPRG 与 RAS 基因激活在儿童急性淋巴细胞白血病中的合作。
Int J Cancer. 2014 Sep 1;135(5):1101-9. doi: 10.1002/ijc.28759. Epub 2014 Feb 19.
3
Inherited GATA3 variants are associated with Ph-like childhood acute lymphoblastic leukemia and risk of relapse.
一种获得性的磷脂酰肌醇 4-磷酸转运起始了 T 细胞恶化和白血病发生。
Nat Commun. 2022 Jul 29;13(1):4390. doi: 10.1038/s41467-022-32104-7.
4
Variant to function mapping at single-cell resolution through network propagation.通过网络传播实现单细胞分辨率下的变体功能映射。
Nat Biotechnol. 2022 Nov;40(11):1644-1653. doi: 10.1038/s41587-022-01341-y. Epub 2022 Jun 6.
5
Variant to function mapping at single-cell resolution through network propagation.通过网络传播实现单细胞分辨率下的变异到功能映射。
bioRxiv. 2022 Jan 24:2022.01.23.477426. doi: 10.1101/2022.01.23.477426.
6
Genome-wide trans-ethnic meta-analysis identifies novel susceptibility loci for childhood acute lymphoblastic leukemia.全基因组跨种族荟萃分析确定了儿童急性淋巴细胞白血病的新易感基因座。
Leukemia. 2022 Mar;36(3):865-868. doi: 10.1038/s41375-021-01465-1. Epub 2021 Nov 8.
7
Somatic Sex: On the Origin of Neoplasms With Chromosome Counts in Uneven Ploidy Ranges.体细胞性征：关于染色体数处于非整倍体范围的肿瘤的起源
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Genes Chromosomes Cancer. 2019 Oct;58(10):723-730. doi: 10.1002/gcc.22765. Epub 2019 May 27.
10
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Leukemia. 2019 Jan;33(1):1-14. doi: 10.1038/s41375-018-0184-z. Epub 2018 Jul 6.
遗传 GATA3 变异与 Ph 样儿童急性淋巴细胞白血病和复发风险相关。
Nat Genet. 2013 Dec;45(12):1494-8. doi: 10.1038/ng.2803. Epub 2013 Oct 20.
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Blood. 2013 Nov 7;122(19):3298-307. doi: 10.1182/blood-2013-03-491316. Epub 2013 Aug 30.
5
The Genotype-Tissue Expression (GTEx) project.基因型-组织表达 (GTEx) 项目。
Nat Genet. 2013 Jun;45(6):580-5. doi: 10.1038/ng.2653.
6
Novel susceptibility variants at 10p12.31-12.2 for childhood acute lymphoblastic leukemia in ethnically diverse populations.在不同种族人群中，10p12.31-12.2 上的新型易感性变异与儿童急性淋巴细胞白血病相关。
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Annotation of functional variation in personal genomes using RegulomeDB.利用 RegulomeDB 注释个人基因组中的功能变异。
Genome Res. 2012 Sep;22(9):1790-7. doi: 10.1101/gr.137323.112.
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Curr Stem Cell Res Ther. 2011 Jun;6(2):142-61. doi: 10.2174/157488811795495431.
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Accurate inference of transcription factor binding from DNA sequence and chromatin accessibility data.从 DNA 序列和染色质可及性数据中准确推断转录因子结合。
Genome Res. 2011 Mar;21(3):447-55. doi: 10.1101/gr.112623.110. Epub 2010 Nov 24.