Komoto Satoshi, Taniguchi Koki
Department of Virology and Parasitology, Fujita Health University School of Medicine.
Uirusu. 2014;64(2):179-90. doi: 10.2222/jsv.64.179.
Rotavirus, a member of the family Reoviridae, was identified as the leading etiological agent of severe gastroenteritis in infants and young children in 1973. The rotavirus genome is composed of 11 gene segments of double-stranded (ds)RNA. During the last 40 years, a large amount of basic research on rotavirus structure, genome, antigen, replication, pathogenesis, epidemiology, immune responses, and evolution has been accumulated. This article reviews the fundamental aspects of rotavirology including recent important achievements in research.
轮状病毒是呼肠孤病毒科的成员，于1973年被确定为婴幼儿严重胃肠炎的主要病原体。轮状病毒基因组由11个双链（ds）RNA基因片段组成。在过去40年里，积累了大量关于轮状病毒结构、基因组、抗原、复制、发病机制、流行病学、免疫反应和进化的基础研究。本文综述了轮状病毒学的基本方面，包括近期研究的重要成果。
