Hitchon P W, Hansen T, McKay T, Girton R A, Dyste G N, Sokoll M D
Department of Surgery, University of Iowa Hospital, Iowa City 52242.
Surg Neurol. 1989 Feb;31(2):101-10. doi: 10.1016/0090-3019(89)90319-4.
To study the effects of the calcium channel blocker nicardipine on spinal cord blood flow and spinal evoked potentials, the following study was undertaken. After cord compression, which was productive of paraparesis, nicardipine was administered intravenously in 10 anesthetized lambs. Ten control animals were subjected to compression but received saline instead. Nicardipine produced a significant decrease in mean arterial pressure when compared to the control group. Thirty minutes after compression, spinal cord blood flow also was lower in the nicardipine group compared with controls. Spinal evoked potentials did not recover after compression in either group.
为研究钙通道阻滞剂尼卡地平对脊髓血流和脊髓诱发电位的影响，进行了以下研究。在造成截瘫的脊髓压迫后，对10只麻醉的羔羊静脉注射尼卡地平。另外10只对照动物接受脊髓压迫，但注射的是生理盐水。与对照组相比，尼卡地平使平均动脉压显著降低。压迫后30分钟，尼卡地平组的脊髓血流也低于对照组。两组在压迫后脊髓诱发电位均未恢复。
