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他汀类药物通过调节凋亡和自噬活性降低格雷夫斯病患者的眼眶病风险。

Statin reduces orbitopathy risk in patients with Graves' disease by modulating apoptosis and autophagy activities.

作者信息

Bifulco Maurizio, Ciaglia Elena

机构信息

Department of Medicine and Surgery, University of Salerno, Via Salvatore Allende, 84081, Baronissi, Salerno, Italy.

出版信息

Endocrine. 2016 Sep;53(3):649-50. doi: 10.1007/s12020-015-0762-z. Epub 2015 Oct 5.

DOI:10.1007/s12020-015-0762-z
PMID:26438397
Abstract

Statins use has been associated with reduced risk for developing orbitopathy among patients with Graves' disease. We hypothesize that statin reduces orbitopathy risk mainly by modulating both apoptosis and autophagy activities in patients with Graves' disease.

摘要

他汀类药物的使用与格雷夫斯病患者发生眼眶病的风险降低有关。我们推测，他汀类药物主要通过调节格雷夫斯病患者的细胞凋亡和自噬活性来降低眼眶病风险。

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Statin reduces orbitopathy risk in patients with Graves' disease by modulating apoptosis and autophagy activities.他汀类药物通过调节凋亡和自噬活性降低格雷夫斯病患者的眼眶病风险。
Endocrine. 2016 Sep;53(3):649-50. doi: 10.1007/s12020-015-0762-z. Epub 2015 Oct 5.
2
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Statins Decrease the Risk of Orbitopathy in Newly Diagnosed Patients with Graves Disease.他汀类药物可降低 Graves 病初诊患者发生眼眶病的风险。
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本文引用的文献

1
Autophagy is involved in the initiation and progression of Graves' orbitopathy.自噬参与Graves眼病的发生和发展。
Thyroid. 2015 Apr;25(4):445-54. doi: 10.1089/thy.2014.0300.
2
Risk factors for developing thyroid-associated ophthalmopathy among individuals with Graves disease.格雷夫斯病患者发生甲状腺相关性眼病的危险因素。
JAMA Ophthalmol. 2015 Mar;133(3):290-6. doi: 10.1001/jamaophthalmol.2014.5103.
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Apoptosis, autophagy and ER stress in mevalonate cascade inhibition-induced cell death of human atrial fibroblasts.
高脂血症和载脂蛋白E与中国人群甲状腺相关性眼病的眼压有关：一项横断面研究。
Front Endocrinol (Lausanne). 2024 Nov 28;15:1484343. doi: 10.3389/fendo.2024.1484343. eCollection 2024.
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Smoking enhances proliferation, inflammatory markers, and immunoglobulins in peripheral blood mononuclear cells from Graves' patients.吸烟会增强格雷夫斯病患者外周血单个核细胞的增殖、炎症标志物及免疫球蛋白水平。
Endocr Connect. 2024 May 6;13(6). doi: 10.1530/EC-23-0374. Print 2024 Jun 1.
5
An Appraisal of the Preventive Effect of Statins on the Development of Graves' Ophthalmopathy: A Hospital-Based Cohort Study.他汀类药物对格雷夫斯眼病发生的预防作用评估：一项基于医院的队列研究。
Ophthalmol Ther. 2024 Jun;13(6):1499-1511. doi: 10.1007/s40123-024-00930-1. Epub 2024 Apr 6.
6
Genetic insights into repurposing statins for hyperthyroidism prevention: a drug-target Mendelian randomization study.他汀类药物在甲状腺功能亢进症预防中的再利用的遗传见解：药物靶点孟德尔随机研究。
Front Endocrinol (Lausanne). 2024 Feb 15;15:1331031. doi: 10.3389/fendo.2024.1331031. eCollection 2024.
7
Statins and thyroid eye disease (TED): a systematic review.他汀类药物与甲状腺眼病（TED）：一项系统综述。
Endocrine. 2024 Jul;85(1):11-17. doi: 10.1007/s12020-023-03680-5. Epub 2024 Jan 9.
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Autophagy in graves' ophthalmopathy.格雷夫斯眼病中的自噬
Front Cell Dev Biol. 2023 Apr 14;11:1158279. doi: 10.3389/fcell.2023.1158279. eCollection 2023.
9
Thyroid eye disease: From pathogenesis to targeted therapies.甲状腺眼病：从发病机制到靶向治疗
Taiwan J Ophthalmol. 2022 Jan 21;12(1):3-11. doi: 10.4103/tjo.tjo_51_21. eCollection 2022 Jan-Mar.
10
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Front Endocrinol (Lausanne). 2021 Feb 1;11:607968. doi: 10.3389/fendo.2020.607968. eCollection 2020.
他汀类药物抑制甲羟戊酸通路诱导人心房成纤维细胞死亡过程中的细胞凋亡、自噬和内质网应激
Cell Death Dis. 2012 Jun 21;3(6):e330. doi: 10.1038/cddis.2012.61.
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Simvastatin alleviates the progression of periapical lesions by modulating autophagy and apoptosis in osteoblasts.辛伐他汀通过调节成骨细胞的自噬和凋亡来缓解根尖病变的进展。
J Endod. 2012 Jun;38(6):757-63. doi: 10.1016/j.joen.2012.02.023. Epub 2012 Apr 6.
5
Novel aspects of mevalonate pathway inhibitors as antitumor agents.新型甲羟戊酸途径抑制剂作为抗肿瘤药物的作用机制。
Clin Cancer Res. 2012 Jul 1;18(13):3524-31. doi: 10.1158/1078-0432.CCR-12-0489. Epub 2012 Apr 23.
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Innate immune activation and thyroid autoimmunity.先天免疫激活与甲状腺自身免疫。
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Effect of statins on the viability of macrophages and smooth muscle cells.他汀类药物对巨噬细胞和平滑肌细胞活力的影响。
J Cardiovasc Pharmacol. 2010 Mar;55(3):269-75. doi: 10.1097/FJC.0b013e3181d0bec3.
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Ocul Immunol Inflamm. 2007 Mar-Apr;15(2):105-11. doi: 10.1080/09273940601186735.