Cooley A J, Van Campen H, Philpott M S, Easterday B C, Hinshaw V S
School of Veterinary Medicine, Department of Pathobiological Sciences, University of Wisconsin, Madison.
Vet Pathol. 1989 Jan;26(1):1-5. doi: 10.1177/030098588902600101.
To determine histopathological damage in the respiratory tract, ducks were inoculated with five different influenza A viruses, including viruses virulent for other avian hosts. Lungs were collected for detection of virus and histopathological examination. Small amounts of infectious virus were recovered from lungs, and viral antigens were demonstrated by immunoperoxidase staining with monoclonal antibodies to the viral nucleoprotein. Although clinical signs were not detected, lungs of ducks infected with both virulent and avirulent viruses had mild pneumonia characterized by infiltrates of lymphocytes and macrophages. These findings show that although clinical signs are not evident, ducks may have damage to the respiratory tract during influenza.
为了确定呼吸道的组织病理学损伤，用五种不同的甲型流感病毒接种鸭子，包括对其他禽类宿主具有致病性的病毒。采集肺组织用于病毒检测和组织病理学检查。从肺中回收了少量传染性病毒，并用针对病毒核蛋白的单克隆抗体通过免疫过氧化物酶染色证实了病毒抗原。尽管未检测到临床症状，但感染了强毒和无毒病毒的鸭子的肺均有轻度肺炎，其特征为淋巴细胞和巨噬细胞浸润。这些发现表明，尽管临床症状不明显，但鸭子在感染流感期间呼吸道可能会受到损伤。
